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The early detection and thus treatment of breast cancer bone metastasis remain a big challenge clinically. As the most abundant cells within bone tissue, osteocytes have been found to manipulate the… Continue Reading
This study describes the simple preparation of core-shell glycosyl gold nanoparticles (AuNPs) using stepwise, copper-free click chemistry-promoted self-assembly. The as-formed glyco-AuNPs can be used… Continue Reading
Construction of composite materials based on the self-assembly of fluorescently labeled biomolecules with a variety of micro- or nano-quenching materials (by the Förster Resonance Energy Transfer… Continue Reading
A 2D "glycosheet" based on supramolecular self-assembly between 2D MoS2 and fluorescent glycoligands is developed. The composite 2D material is proven suitable for targeted intracellular production… Continue Reading
In this review we will explore recent advances in the design and application of excited-state intramolecular proton-transfer (ESIPT) based fluorescent probes. Fluorescence based sensors and imaging… Continue Reading
Never-theless, although these glycosylations proceeded smoothly and afforded effectively the final product, there still remain several drawbacks such as incomplete anomeric retention, relatively low… Continue Reading
Developing an effective means for the real-time probing of amyloid β (Aβ) that is closely implicated in Alzheimer's disease (AD) could help better understand and monitor the disease. Here we describe… Continue Reading
A copper(I)-catalyzed azide-alkyne cycloaddition reaction (CuAAC) is employed for the click chemistry approach towards novel PTP inhibitors (IV).
Ever since the discovery of graphene, increasing efforts have been devoted to the use of this stellar material as well as the development of other graphene-like materials such as thin-layer… Continue Reading