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OBJECTIVE To increase the speed of a distortion product otoacoustic emissions (DPOE) test of cochlear function by employing a new multiple-tone-pair method and to validate the method. DESIGN We used a new method of employing multiple tone pairs in measuring DPOEs proposed by Zurek and Rabinowitz and implemented in a modified Grason-Stadler Model GSI-60.(More)
CBA mice do not exhibit age-related loss of auditory sensitivity or cochlear pathology until relatively late in life. Therefore, this strain is believed to be an excellent animal model for the examination of the effects of age on the cochlea. To evaluate the effects of age on outer hair cell function, 2f1-f2 distortion product otoacoustic emissions (DPOAEs)(More)
The performance of distortion product otoacoustic emissions (DPOEs) as a frequency-specific test of sensorineural hearing loss was evaluated in 142 ears of human adults with normal middle-ear function. The DPOE was measured with the stimulus levels of the two tones equal to 65 dB SPL (re 20 mu Pa) and the ratio between the two frequencies 1.2. In the DPOE(More)
The fine structure of the 2f1-f2 acoustic distortion product (ADP) as a function of frequency has been measured in human subjects and shows a series of sharp peaks and valleys (rippling) with peak-to-valley level differences of up to 15-20 dB. In order to delineate the cause of the ADP rippling pattern, a computer model was developed to simulate the(More)
The phenomenon of efferent-mediated adaptation of 2f1-f2 distortion product otoacoustic emission (DPOAE) was investigated in two strains (CBA/JNia and C57BL/6JNia) of mice of various ages using stimuli presented monaurally or binaurally. The present study demonstrated the existence of the DPOAE adaptation phenomenon in mice analogous to that previously(More)
Distortion product otoacoustic emissions (DPOEs) at the frequency of 2f1 -f2 (f1 < f2) were measured in 77 human adult ears with normal hearing or sensorineural hearing loss. The purpose of this study was to compare the performances of DPOE tests conducted with two sets of stimuli: 1) L1 = 65, L2 = 50 dB sound pressure level (SPL) re 20 microPa ("65/50"),(More)
The low-speed spin-coating method was developed to prepare uniform and interconnected silver nanowires (AgNWs) film with the transmittance of 95% and sheet resistance of 20Ω/sq on glass, which was comparable to ITO. The fitting value of σ dc/σ op of 299.3 was attributed to the spin-coating process. Advantages of this solution-processed AgNW film on AlGaInP(More)
Malignant mesothelioma (MM) is an aggressive, fatal tumor strongly associated with asbestos exposure. There is an urgent need to improve MM patient outcomes and this requires functionally validated pre-clinical models. Mesothelioma-derived cell lines provide an essential and relatively robust tool and remain among the most widely used systems for candidate(More)
In order to prominently investigate the effects of the surface spin on the magnetic properties, the weak magnetic ZnLa0.02Fe1.98O4 nanoparticles were chosen as studying objects which benefit to reduce as possibly the effects of interparticle dipolar interaction and crystalline anisotropy energies. By annealing the undiluted and diluted ZnLa0.02Fe1.98O4(More)
UNLABELLED Suspended micromachined porous silicon beams with laterally uniform porosity are reported, which have been fabricated using standard photolithography processes designed for compatibility with complementary metal-oxide-semiconductor (CMOS) processes. Anodization, annealing, reactive ion etching, repeated photolithography, lift off and(More)