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AIM Currently, there is considerable debate as to which method is more accurate for measuring the activity of CYP3A in vivo: cortisol 6beta-hydroxylation clearance (Cl(m(6beta))) or the urinary ratio of 6beta-OHF to F (6beta-OHF/F). Furthermore, the value of measuring endogenous levels of cortisol over a 24 h period (AUC(F)) needs to be confirmed. The aim(More)
OBJECTIVE To study the morphology of the soft palate in normal humans with digital radiography and to provide the references for therapy of the cleft. METHODS 106 normal people were involved. The morphology of the soft palate was observed with digital cephalometry. RESULTS All static images of soft palate could be divided into six types: Shuttle-shaped,(More)
Collapsible graph Locally connected graphs Locally k-edge-connected a b s t r a c t Given two nonnegative integers s and t, a graph G is (s, t)-supereulerian if for any disjoint sets X , Y ⊂ E(G) with |X| ≤ s and |Y | ≤ t, there is a spanning eulerian subgraph H of G that contains X and avoids Y. We prove that if G is connected and locally k-edge-connected,(More)
OBJECTIVE The present bioequivalence study was designed to compare the newly-developed levamlodipine besylate 2.5-mg tablet (test) with that of its 2.5-mg marketed counterpart (reference) in healthy Chinese adult male volunteers. METHODS A single-dose, randomized, open-label, two-period, and two-treatment self-crossover study was conducted in healthy(More)
OBJECTIVE The present study was designed to evaluate the bioequivalence of a newly developed sildenafil citrate tablet 50 mg (Jinge<sup>®</sup>, Test) and a marketed counterpart (Viagra<sup>®</sup>, 100 mg, Reference) in healthy adult male Chinese volunteers. METHODS This single-dose, randomized, open-label, four-period, and two-treatment self-crossover(More)