Xiao-Jian Shao

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As one of the most important and universal posttranslational modifications (PTMs) of proteins, S-nitrosylation (SNO) plays crucial roles in a variety of biological processes, including the regulation of cellular dynamics and many signaling events. Knowledge of SNO sites in proteins is very useful for drug development and basic research as well.(More)
Post-translational modifications (PTMs) play crucial roles in various cell functions and biological processes. Protein hydroxylation is one type of PTM that usually occurs at the sites of proline and lysine. Given an uncharacterized protein sequence, which site of its Pro (or Lys) can be hydroxylated and which site cannot? This is a challenging problem, not(More)
The automatic classification for protein structure plays an important role in bioinformatics. Here we present an improved multiclass SVM for the classification based on the features of the protein structure which were extracted from the protein convex hull. Firstly, we modify the gauss radial kernel by adding a positive constant to the kernel function.(More)
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