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The fragile X mental retardation syndrome is due to the transcriptional silence of the fragile X gene, FMR1, and to the resulting loss of the FMR1 product, FMRP. The pathogenesis of the syndrome, however, is not understood. Increased prevalence of childhood seizures is a feature of the fragile X syndrome and increased seizure susceptibility is seen in the(More)
The possibility that the GABAA receptor is involved in supraspinal morphine analgesia was investigated in rats using pentobarbital and other GABAA receptor-chloride channel ligands. Inhibition of tail-flick was used as an index of analgesia. Pentobarbital almost completely reversed intracerebroventricular (i.c.v.) morphine analgesia, but did not affect(More)
The relationships among parental origin of the fragile X gene, gene structure, and specific cognitive deficits were evaluated in nonretarded adult female fragile X carriers to determine whether: (1) origin influences gene structure and cognitive function, (2) mild cognitive impairments are associated with altered gene structure, and (3) specific cognitive(More)
Electroacupuncture has been shown to increase met- and leu-enkephalin contents in rat striatum and hypothalamus. Its mechanism was further studied by measuring the levels of the large molecular weight enkephalin containing peptides (LECP), processed intermediates, free leu-enkephalin as well as proenkephalin mRNA in the striatum of rats decapitated at(More)
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