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HDAC6 is a microtubule-associated deacetylase
The results show that HDAC6 is the tubulin deacetylase, and provide evidence that reversible acetylation regulates important biological processes beyond histone metabolism and gene transcription, including microtubule-dependent cell motility.
TGFβ signals through a heteromeric protein kinase receptor complex
Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway.
Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase
Functional Analysis of the Transforming Growth Factor βResponsive Elements in the WAF1/Cip1/p21 Promoter (*)
- M. Datto, Yong Yu, Xiao-Fan Wang
- Biology, ChemistryThe Journal of Biological Chemistry
- 1 December 1995
A 10-base pair sequence is defined that is required for the activation of the p21 promoter and is sufficient to drive TGF-β-mediated transcription from a previously nonresponsive promoter in the case of p21.
Notch Promotes Radioresistance of Glioma Stem Cells
It is shown that inhibition of Notch pathway with γ‐secretase inhibitors (GSIs) renders the glioma stem cells more sensitive to radiation at clinically relevant doses, and a critical role of notch signaling to regulate radioresistance of gliomas stem cells is suggested.
Signaling cross-talk between TGF-β/BMP and other pathways
The different modes of cross-talk between TGF-β/BMP and the signaling pathways of Mitogen-activated protein kinase, phosphatidylinositol-3 kinase/Akt, Wnt, Hedgehog, Notch, and the interleukin/interferon-gamma/tumor necrosis factor-alpha cytokines are reviewed, with an emphasis on the underlying molecular mechanisms.
TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma.
Acquired Expression of Periostin by Human Breast Cancers Promotes Tumor Angiogenesis through Up-Regulation of Vascular Endothelial Growth Factor Receptor 2 Expression
The identification of periostin as a mesenchyme-specific gene whose acquired expression by human breast cancers leads to a significant enhancement in tumor progression and angiogenesis is described.
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis
Findings determine how this microRNA pair alters the composition of the primary tumour microenvironment to favour breast cancer metastasis, and demonstrate a correlation between miR-126/126* downregulation and poor metastasis-free survival of breast cancer patients.