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Gambogic Acid Induces Apoptosis in Imatinib-Resistant Chronic Myeloid Leukemia Cells via Inducing Proteasome Inhibition and Caspase-Dependent Bcr-Abl Downregulation
Findings suggest an alternative strategy to overcome imatinib resistance by enhancing Bcr-Abl downregulation with the medicinal compound gambogic acid, which may have great clinical significance inImatinib-resistant cancer therapy.
Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth
This study uncovers the first drug already used in clinic that can inhibit proteasome-associated DUBs with promising anti-tumor effects.
Triptolide Inhibits Bcr-Abl Transcription and Induces Apoptosis in STI571-resistant Chronic Myelogenous Leukemia Cells Harboring T315I Mutation
Triptolide is a promising agent to overcome STI571-resistant CML cells, and warrant a clinical trial of triptolide derivatives for CML with Bcr-Abl-T315I mutation.
Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms
Findings support that Auranofin overcomes IM resistance through both Bcr/Abl-dependent and -independent mechanisms, providing great clinical significance for cancer treatment.
Circadian clock cryptochrome proteins regulate autoimmunity
- Q. Cao, Xuan Zhao, H. P. Koeffler
- Biology, MedicineProceedings of the National Academy of Sciences
- 6 November 2017
It is shown that mice deficient of the circadian clock genes Cry1 and Cry2 unexpectedly display an autoimmune phenotype including high serum IgG concentrations, the presence of serum antinuclear antibodies, and precipitation of IgG, IgM, and complement 3 in glomeruli and massive infiltration of leukocytes into the lungs and kidneys.
GDP366, a novel small molecule dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells
GDP366 is a novel dual inhibitor of survivin and Op18 which significantly inhibited the growth of tumor cells in vitro and in vivo without rapid induction of apoptosis and induced polyploidy in multiple types of cancer cell lines.
Cyclin-Dependent Kinase 7/9 Inhibitor SNS-032 Abrogates FIP1-like-1 Platelet-Derived Growth Factor Receptor α and Bcr-Abl Oncogene Addiction in Malignant Hematologic Cells
This CDK7/9 inhibitor potently inhibits FIP1L1-PDGFRα–positive HES cells and Bcr-Abl–positive CML cells regardless of their sensitivity to imatinib, and may have potential in treating hematologic malignancy by abrogating oncogene addiction.
Gambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibition
Gambogic acid induced growth inhibition and apoptosis of both GCB- and ABC-DLBCL cells in vitro and in vivo, which is associated with proteasome malfunction provides significant pre-clinical evidence for potential usage of GA in DLBCL therapy particularly in ABC-DMCL treatment.
Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1
It is demonstrated that super-enhancer-associated transcripts are significantly enriched in EWS-FLI1 target genes, contribute to the aberrant transcriptional network of the disease, and mediate the exceptional sensitivity of Ewing sarcoma to transcriptional inhibition.
Platinum-containing compound platinum pyrithione is stronger and safer than cisplatin in cancer therapy