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NOPO modulates Egr-induced JNK-independent cell death in Drosophila
Tumor necrosis factor (TNF) family ligands play essential roles in regulating a variety of cellular processes including proliferation, differentiation and survival. Expression of Drosophila TNFExpand
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Hippo signaling promotes JNK-dependent cell migration
  • Xianjue Ma, H. Wang, +6 authors L. Xue
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 7 February 2017
Significance Cancer is the leading cause of death worldwide, although studies revealed that dysregulation of the Hippo pathway contributes to tumorigenesis, whereas its roles in tumor invasion andExpand
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dUev1a modulates TNF-JNK mediated tumor progression and cell death in Drosophila.
Loss of cell polarity cooperates with oncogenic Ras to induce JNK-dependent tumor growth and invasion. To identify additional genes that modulate tumor progression, we have performed a genetic screenExpand
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PP6 Disruption Synergizes with Oncogenic Ras to Promote JNK-Dependent Tumor Growth and Invasion.
RAS genes are frequently mutated in cancers, yet an effective treatment has not been developed, partly because of an incomplete understanding of signaling within Ras-related tumors. To address this,Expand
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Impaired Hippo signaling promotes Rho1–JNK-dependent growth
  • Xianjue Ma, Y. Chen, +6 authors L. Xue
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 12 January 2015
Significance Both Hippo and c-Jun N-terminal kinase (JNK) signaling have well-established roles in promoting tissue growth, while it remains elusive whether and how the two pathways interact orExpand
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POSH regulates Hippo signaling through ubiquitin-mediated expanded degradation
Significance Here we performed a genetic screen in Drosophila and identified POSH (Plenty of SH3s), an E3 ubiquitin ligase, as a regulator of Hippo pathway. We found POSH ubiquitinates and degradesExpand
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Wingless modulates activator protein-1-mediated tumor invasion
Metastasis begins with a subset of local tumor cells acquiring the potential to invade into surrounding tissues, and remains to be a major obstacle for cancer treatments. More than 90% of cancerExpand
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Context-dependent interplay between Hippo and JNK pathway in Drosophila
Both Hippo and JNK signaling have well-established roles in regulating many physiological processes, including cell proliferation, growth, survival, and migration. An increasing body of evidenceExpand
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Spz/Toll-6 signal guides organotropic metastasis in Drosophila
ABSTRACT Targeted cell migration plays important roles in developmental biology and disease processes, including in metastasis. Drosophila tumors exhibit traits characteristic of human cancers,Expand
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The dark side of hippo signaling: A cancer promoter role
ABSTRACT The Hippo signaling pathway regulates organ size and tissue homeostasis. Given this role it is unsurprising that dysregulation of this pathway has implications for cancer progression. AExpand
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