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- Publications
- Influence
NOPO modulates Egr-induced JNK-independent cell death in Drosophila
- Xianjue Ma, J. Huang, Lixia Yang, Y. Yang, W. Li, L. Xue
- Biology, Medicine
- Cell Research
- 1 February 2012
Tumor necrosis factor (TNF) family ligands play essential roles in regulating a variety of cellular processes including proliferation, differentiation and survival. Expression of Drosophila TNF… Expand
Hippo signaling promotes JNK-dependent cell migration
- Xianjue Ma, H. Wang, +6 authors L. Xue
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 7 February 2017
Significance Cancer is the leading cause of death worldwide, although studies revealed that dysregulation of the Hippo pathway contributes to tumorigenesis, whereas its roles in tumor invasion and… Expand
dUev1a modulates TNF-JNK mediated tumor progression and cell death in Drosophila.
- Xianjue Ma, Lixia Yang, Y. Yang, Maoquan Li, Wenzhe Li, Lei Xue
- Biology, Medicine
- Developmental biology
- 15 August 2013
Loss of cell polarity cooperates with oncogenic Ras to induce JNK-dependent tumor growth and invasion. To identify additional genes that modulate tumor progression, we have performed a genetic screen… Expand
PP6 Disruption Synergizes with Oncogenic Ras to Promote JNK-Dependent Tumor Growth and Invasion.
- Xianjue Ma, Jin-yu Lu, Yongli Dong, Daming Li, Juan N Malagon, T. Xu
- Biology, Medicine
- Cell reports
- 27 June 2017
RAS genes are frequently mutated in cancers, yet an effective treatment has not been developed, partly because of an incomplete understanding of signaling within Ras-related tumors. To address this,… Expand
Impaired Hippo signaling promotes Rho1–JNK-dependent growth
- Xianjue Ma, Y. Chen, +6 authors L. Xue
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 12 January 2015
Significance Both Hippo and c-Jun N-terminal kinase (JNK) signaling have well-established roles in promoting tissue growth, while it remains elusive whether and how the two pathways interact or… Expand
POSH regulates Hippo signaling through ubiquitin-mediated expanded degradation
- Xianjue Ma, Xiao-wei Guo, H. Richardson, T. Xu, L. Xue
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 12 February 2018
Significance Here we performed a genetic screen in Drosophila and identified POSH (Plenty of SH3s), an E3 ubiquitin ligase, as a regulator of Hippo pathway. We found POSH ubiquitinates and degrades… Expand
Wingless modulates activator protein-1-mediated tumor invasion
- S. Zhang, Xiao-wei Guo, +11 authors L. Xue
- Biology, Medicine
- Oncogene
- 25 January 2019
Metastasis begins with a subset of local tumor cells acquiring the potential to invade into surrounding tissues, and remains to be a major obstacle for cancer treatments. More than 90% of cancer… Expand
Context-dependent interplay between Hippo and JNK pathway in Drosophila
- Xianjue Ma
- Biology
- 8 December 2014
Both Hippo and JNK signaling have well-established roles in regulating many physiological processes, including cell proliferation, growth, survival, and migration. An increasing body of evidence… Expand
Spz/Toll-6 signal guides organotropic metastasis in Drosophila
- Ketu Mishra-Gorur, D. Li, Xianjue Ma, Yanki Yarman, L. Xue, T. Xu
- Biology, Medicine
- Disease Models & Mechanisms
- 1 October 2019
ABSTRACT Targeted cell migration plays important roles in developmental biology and disease processes, including in metastasis. Drosophila tumors exhibit traits characteristic of human cancers,… Expand
The dark side of hippo signaling: A cancer promoter role
- Brandon Dunn, Xianjue Ma
- Biology, Medicine
- Fly
- 2 June 2017
ABSTRACT The Hippo signaling pathway regulates organ size and tissue homeostasis. Given this role it is unsurprising that dysregulation of this pathway has implications for cancer progression. A… Expand