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BACKGROUND Stromal interaction molecule 1 (STIM1) is a newly discovered Ca2+ sensor on the endoplasmic reticulum which is an indispensable part in the activation of store-operated Ca2+ channels (SOC). Recent studies demonstrate that SOC of pulmonary smooth muscle cells (PASMCs) were upregulated by chronic hypoxia which contribute to the enhanced pulmonary(More)
activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract Human and animal studies have converged to suggest that caffeine consumption prevents(More)
Extracellular matrix metalloproteinase inducer (EMMPRIN) reportedly has a key regulatory role in matrix metalloproteinase (MMP) activities and the progression of atherosclerosis. Statins, which are anti-atherosclerotic pharmacological agents, are widely applied in clinical settings. The aim of the present study was to investigate the pharmaceutical effect(More)
Cervical artery dissection (CAD) is an important cause of stroke for young patients, accounting for 5-22% of strokes in patients <45 years of age, which presents not only a great burden to the stroke victims but also a financial burden to the family and society. Because CAD can lead to different clinical lesions, including neuropathy, acute ischemic stroke,(More)
Human and animal studies have converged to suggest that caffeine consumption prevents memory deficits in aging and Alzheimer's disease through the antagonism of adenosine A 2A receptors (A 2A R). To test if A 2A R activation in hippocampus is actually sufficient to impair memory function and to begin elucidating the intracellular pathways operated by A 2A(More)
Adenosine A2A receptors (A2ARs) in distinct cellular types may exert different and even opposite effects on many neurologic disorders; A2ARs in bone marrow-derived cells (BMDCs) have been shown to play important roles in various brain injuries. We previously showed that global A2AR inactivation aggravates chronic cerebral hypoperfusion-induced white matter(More)
Background: Stromal interaction molecule 1 (STIM1) is a newly discovered Ca sensor on the endoplasmic reticulum which is an indispensable part in the activation of store-operated Ca channels (SOC). Recent studies demonstrate that SOC of pulmonary smooth muscle cells (PASMCs) were upregulated by chronic hypoxia which contribute to the enhanced pulmonary(More)
Hollow porous NiCo2O4-nanoboxes (NCO-NBs) were synthesized with zeolitic imidazolate framework-67 (ZIF-67) nanocrystals as the template followed by a subsequent annealing treatment. The structure and morphology of the NCO-NBs were characterized using X-ray diffraction, field emission scanning electron microscopy and transmission electron microscopy. When(More)
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