Xiangyun Wang

Learn More
This paper describes an approach to data-driven discovery of decision trees or rules for assigning protein sequences to functional families using sequence motifs. This method is able to capture regularities that can be described in terms of presence or absence of arbitrary combinations of motifs. A training set of peptidase sequences labeled with the(More)
This paper describes an approach to data-driven discovery of sequence motif-based models in the form of decision trees for assigning protein sequences to functional families. Unlike approaches that try to classify protein sequences based on presence of a single motif, this method is able to capture regularities that can be described in terms of presence or(More)
BACKGROUND The global gene expression profiles of adult and fetal murine prostate stem cells were determined to define common and unique regulators whose misexpression might play a role in the development of prostate cancer. METHODOLOGY/PRINCIPAL FINDINGS A distinctive core of transcriptional regulators common to both fetal and adult primitive prostate(More)
This paper describes an approach to data-driven discovery of decision trees or rules for assigning protein sequences to functional families using sequence motifs. This method is able to capture regularities that can be described in terms of presence or absence of arbitrary combinations of motifs. A training set of peptidase sequences labeled with the(More)
BACKGROUND Signals between stem cells and stroma are important in establishing the stem cell niche. However, very little is known about the regulation of any mammalian stem cell niche as pure isolates of stem cells and their adjacent mesenchyme are not readily available. The prostate offers a unique model to study signals between stem cells and their(More)
Cyclopamine (CPM) showed promise as a human cancer chemotherapy agent. However, limitations such as stomach acid instability and low solubility impair its clinical application. In this study, we synthesized a novel CPM analogue, isocyclopamine (ICPM), which had comparative bioactivity with CPM and improved stability and solubility. ICPM reversed doxorubicin(More)
In this paper, we propose and establish an analysis and decision support system based on smart phone for tourist flows, including smart phone based area traffic monitoring and real-time decision support subsystem, traveling by car passenger analysis and decision support subsystem. We give out the system architecture, software design, and related research(More)