Xiangyu Yang

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A new kind of ultrasmall dissociable AuNR@PEG/PLGA vesicles (≈60 nm) (AuNR = gold nanorod; PEG = poly(ethylene glycol); PLGA = poly(lactic-co-glycolic acid)) assembled from small AuNRs (dimension: ≈8 nm × 2 nm) is reported. They exhibit several striking features: prolonged circulation and prominent tumor accumulation; rapid excretion from the body as(More)
Tumor microvasculature possesses a high degree of heterogeneity in its structure and function. These features have been demonstrated to be important for disease diagnosis, response assessment, and treatment planning. The exploratory efforts of quantifying tumor vascular heterogeneity with DCE-MRI have led to promising results in a number of studies.(More)
Relaxometric measurement of the effective transverse relaxation rate R2* plays an important role in the quantitative evaluation of brain function, perfusion, and tissue iron content. However, accurate measurement of R2* is prone to macroscopic background field inhomogeneity. In clinical applications and systems, postprocessing correction techniques are more(More)
We report a hybrid reduced graphene oxide (rGO)-loaded ultrasmall plasmonic gold nanorod vesicle (rGO-AuNRVe) (∼65 nm in size) with remarkably amplified photoacoustic (PA) performance and photothermal effects. The hybrid vesicle also exhibits a high loading capacity of doxorubicin (DOX), as both the cavity of the vesicle and the large surface area of the(More)
A novel color image segmentation method based on finite Gaussian mixture model is proposed in this paper. First, we use EM algorithm to estimate the distribution of input image data and the number of mixture components is automatically determined by MML criterion. Then the segmentation is carried out by clustering each pixel into appropriate component(More)
OBJECTIVES The objective of this study was to assess the capability of T2-weighted magnetic resonance imaging (T2W-MRI) and the additional diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) using multitransmit 3 T in the localization of bladder cancer. MATERIALS AND METHODS This prospective study was approved by the local institutional review(More)
PURPOSE To compare the intraindividual differences of dynamic signal characteristics for 3 gadolinium chelates (gadopentetate dimeglumine [Gd-DTPA], gadodiamide [Gd-DTPA-BMA], and gadobenate dimeglumine [Gd-BOPTA]) using dynamic contrast enhanced magnetic resonance (MR) imaging (DCE-MRI) with a preclinical beagle model at 7 Tesla. METHOD AND MATERIALS(More)
PURPOSE To apply k-means clustering of two pharmacokinetic parameters derived from 3T dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to predict the chemotherapeutic response in bladder cancer at the mid-cycle timepoint. MATERIALS AND METHODS With the predetermined number of three clusters, k-means clustering was performed on(More)