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A novel color image segmentation method based on finite Gaussian mixture model is proposed in this paper. First, we use EM algorithm to estimate the distribution of input image data and the number of mixture components is automatically determined by MML criterion. Then the seg-mentation is carried out by clustering each pixel into appropriate component(More)
Chronic pain is a pathological condition that results in significant loss of life quality, but so far no specific treatment for chronic pain has been developed. Currently available analgesia drugs are either not specific enough or have severe side effects. Therefore a non-invasive approach with high specificity to inhibit nociception becomes essential. In(More)
OBJECTIVE Subjective tinnitus is hypothesized to arise from aberrant neural activity; however, its neural bases are poorly understood. To identify aberrant neural networks involved in chronic tinnitus, we compared the resting-state functional magnetic resonance imaging (fMRI) patterns of tinnitus patients and healthy controls. MATERIALS AND METHODS(More)
Relaxometric measurement of the effective transverse relaxation rate R2* plays an important role in the quantitative evaluation of brain function, perfusion, and tissue iron content. However, accurate measurement of R2* is prone to macroscopic background field inhomogeneity. In clinical applications and systems, postprocessing correction techniques are more(More)
One of the most powerful features of the dynamic contrast-enhanced (DCE) MRI technique is its capability to quantitatively measure the physiological or pathophysiological environments assessed by the passage of contrast agent by means of model-based pharmacokinetic analysis. The widely used two-compartment pharmacokinetic model developed by Brix and(More)
Tumor microvasculature possesses a high degree of heterogeneity in its structure and function. These features have been demonstrated to be important for disease diagnosis, response assessment, and treatment planning. The exploratory efforts of quantifying tumor vascular heterogeneity with DCE-MRI have led to promising results in a number of studies.(More)
AIMS To precisely characterize the penumbra by MRI based on a modified photothrombotic stroke mouse model. METHODS The proximal middle cerebral artery was occluded by a convenient laser system in conjunction with an intravenous injection of Rose Bengal in mice. And the suture MCAO model was performed in seven mice as a comparison of the reproducibility.(More)