Xiangying Guan

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Sirtuins are key regulators of many cellular functions including cell growth, apoptosis, metabolism, and genetic control of age-related diseases. Sirtuins are themselves regulated by their cofactor nicotinamide adenine dinucleotide (NAD+) as well as their reaction product nicotinamide (NAM), the physiological concentrations of which vary during the process(More)
Recently, calcification was observed on implanted intraocular lens (IOL) surfaces when viscoelastic substances were applied during surgery. To elucidate the mechanisms of mineral formation, the crystallization of calcium phosphates on IOL surfaces was studied in vitro with nanomolar sensitivity using a constant composition method. Three different commercial(More)
The authors would like to provide the expressions for K 1 ,K 2 ,K 3 , K m,NAD+ and v max for Equation 3, which should have been included as a supplementary file with the article. The expressions for K 1 ,K 2 ,K 3 ,K m,NAD+ and v max are provided in S1 File in this Correction. Supporting Information S1 File. Initial rate model for sirtuin deacetylation(More)
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