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  • Imma Fernandez, Josep Ubach, Irina Dulubova, Xiangyang Zhang, Thomas C Südhof, Josep Rizo
  • 1998
Syntaxin 1A plays a central role in neurotransmitter release through multiple protein-protein interactions. We have used NMR spectroscopy to identify an autonomously folded N-terminal domain in syntaxin 1A and to elucidate its three-dimensional structure. This 120-residue N-terminal domain is conserved in plasma membrane syntaxins but not in other(More)
Synaptotagmin I is a synaptic vesicle protein that is thought to act as a Ca2+ sensor in neurotransmitter release. The first C2 domain of synaptotagmin I (C2A domain) contains a bipartite Ca2+-binding motif and interacts in a Ca2+-dependent manner with syntaxin, a central component of the membrane fusion complex. Analysis by nuclear magnetic resonance(More)
Multivariate Granger causality is a well-established approach for inferring information flow in complex systems, and it is being increasingly applied to map brain connectivity. Traditional Granger causality is based on vector autoregressive (AR) or mixed autoregressive moving average (ARMA) model, which are potentially affected by errors in parameter(More)
MicroRNAs have emerged as crucial regulators of tumorigenesis. However, it remains unknown whether miR-181a is involved in the pathogenesis of gastric cancer. In this study, we found that miR-181a is overexpressed in human gastric cancer tissues. Ectopic expression of miR-181a mimic promoted the proliferation, colony formation, migration, and invasion and(More)
Live video streaming applications have gained great popularity among users but exert great pressure on video servers and the Internet. Peer-to-Peer (P2P) networks provide an attractive solution due to their low cost and high scalability. A large number of P2P live video streaming schemes have been proposed and many deployments have appeared on the Internet.(More)
—Several push-pull hybrid peer-to-peer (P2P) video live streaming schemes introduce data-driven push trees into the pull scheme and have a short playback delay while being robust against peer churn, but the substrate Internet utilization remains unaddressed. In this paper, we propose TreeClimber, a network-driven robust push-pull scheme for large-scale P2P(More)
BACKGROUND The awareness, treatment and control of diabetes mellitus (DM) can effectively reflect on the social status of diabetes conditions. Although several researchers have investigated the awareness, treatment and control rates of diabetes mellitus in China, little is known about their association with risk factors. This study aims to examine the(More)