Xiangxian Zhang

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BACKGROUND Promoter methylation is an alternative mechanism of gene silencing in human tumorigenesis. Although a number of methylated genes have been found in non small cell lung cancer (NSCLC), useful methylation markers for early prognostic evaluation of NSCLC remain largely unknown. METHODS Using methylation-specific PCR (MSP), we examined promoter(More)
The selection of an appropriate threshold is one of the main concerns about the POT (Peaks Over Threshold ) model, which is widely used in many fields, such as in insurance and environmental analysis. In this article, a new method which is based on the MSE criterion and two-sample K-S tests is proposed to determine the optimal threshold in the GPD model.(More)
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