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MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2.
The results indicate that miR-26a functions as a growth-suppressive miRNA in NPC, and that its suppressive effects are mediated chiefly by repressing EZH2 expression.
Exosomal miR-9 inhibits angiogenesis by targeting MDK and regulating PDK/AKT pathway in nasopharyngeal carcinoma
Mechanistic analyses revealed that exosomal miR-9 from NPC cells inhibited endothelial tube formation and migration by targeting MDK and regulating PDK/AKT signaling pathway, and the level of MDK was upregulated in NPC tumor samples and was positively correlated with microvessel density.
Detailed analysis of inflammatory cell infiltration and the prognostic impact on nasopharyngeal carcinoma
The analysis was presented, providing a comprehensive characterization of antitumor inflammatory response in NPC, and showed the presence of a very abundant immune cells infiltrate containing mainly T‐lymphocytes.
Epstein‐Barr virus nuclear antigen 1 (EBNA1) protein induction of epithelial‐mesenchymal transition in nasopharyngeal carcinoma cells
The objective of this study was to investigate the role of EBNA1 protein in nasopharyngeal carcinoma (NPC) and to propose a new treatment strategy for this disease.
Diagnostic and prognostic value of plasma microRNA deregulation in nasopharyngeal carcinoma
Plasma miRNA expression is a useful biomarker for NPC diagnosis but not for its prognosis, and combination of several plasma miRNAs can increase both NPC diagnostic sensitivity and specificity.
miR-26a inhibits invasion and metastasis of nasopharyngeal cancer by targeting EZH2
It is shown that ectopic expression of miR-26a inhibited the migratory and invasive capacities of NPC cells in vitro and in vivo and that its antimetastatic effects are mediated mainly by repressing EZH2 expression.
Levels of plasma Epstein-Barr virus DNA prior and subsequent to treatment predicts the prognosis of nasopharyngeal carcinoma.
Data indicated that pre- and post-treatment levels of plasma EBV-DNA were able to predict the prognosis of NPC, and may provide novel references for research and clinical practice.
TBX2 and TBX3: The special value for anticancer drug targets
EZH2 promotes angiogenesis through inhibition of miR-1/Endothelin-1 axis in nasopharyngeal carcinoma
The results identify a novel signaling pathway involved in NPC angiogenesis, and suggest that EZH2-miR-1-ET-1 axis represents multiple potential therapeutic targets for NPC.