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Severe myocardial dysfunction and tissue damage resulting from ischemia/reperfusion (I/R) is a common clinical scenario in patients with certain types of heart diseases and therapies such as thrombolysis, percutaneous coronary intervention, coronary artery bypass grafting, and cardiac transplantation. The underlining mechanism of endogenous cardiac(More)
As critical DNA structures capping the human chromosome ends, the stability and structural polymorphism of human telomeric G-quadruplex (G4) have drawn increasing attention in recent years. This work characterizes the equilibrium transitions of single-molecule telomeric G4 at physiological K(+) concentration. We report three folded states of telomeric G4(More)
Bone marrow-derived mesenchymal stem cells (BMSCs) have shown great promise for ischemic tissue repair. However, poor viability of transplanted BMSCs within ischemic tissues has limited their therapeutic potential. Apelin, an endogenous peptide, whose level is elevated following ischemia, has been shown to enhance survival of cardiomyocytes and neuronal(More)
BACKGROUND/AIMS Epoxyeicosatrienoic acids (EETs), a type of lipid mediators produced by cytochrome P450 epoxygenases, exert anti-inflammatory, angiogenic, anti-oxidative and anti-apoptotic effects. However, the role of EETs in cigarette smoke-induced lung injury and the underlying mechanisms are not fully known. The aim of this study was to explore the(More)
This paper proposes a multiagent-based adaptive wide-area current differential protection system. A power grid is divided into primary and backup protection zones dynamically online with the help of a developed expert system, and the relay agents of these zones cooperate to perform a differential relaying function. Predictive self-healing strategies have(More)
The full-size converters for wind turbine systems can flexibly realize variable-speed control and meet power system operational requirements. The designs of two-level, three-level neutral point clamped and three-level flying capacitor converter as full-size back-to-back converters for large wind turbine system are discussed in this paper. The harmonic(More)
The present study was to test the hypothesis that 11,12-epoxyeicosatrienoic acid (11,12-EET), a metabolic product of arachidonic acid by cytochrome P450 epoxygenase, regulates nitric oxide (NO) generation of the L-arginine/NO synthase (NOS) pathway in human platelets. Human platelets were incubated in the presence or absence of different concentrations of(More)
Many mine power systems operate with a floating neutral or are high-resistance grounded, and earth fault current is no more than a few tens of amperes. Traditional earth-fault-detection methods based on zero-sequence current have poor sensitivity in this case. For improvement, a fault-detection scheme with fault-current and fault-resistance measurement is(More)