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Synthesis of gibberellin derivatives with anti-tumor bioactivities.
TLDR
Gibberellin derivatives bearing two alpha,beta-unsaturated ketone units showed strong anticancer activities in MTT assay towards a number of human cancer cell lines including HT29, A549, HepG2 and MKN28. Expand
Synthesis and antitumor activity of 1-mesityl-3-(2-naphthoylmethano)-1H-imidazolium bromide.
TLDR
In vitro studies demonstrate that MNIB is active against K562, SMMC-7721, EJ, AGZY, HEP-2, A549, HepG2, and Raji tumor cells, and can induce the G1 phase cell cycle arrest and apoptosis in K562 cells. Expand
Three new phenanthrenes from Monomeria barbata Lindl.
Abstract Three new monophenanthrene compounds were isolated from an acetone extract of the tubers of Monomeria barbata Lindl. (Orchidaceae). Using spectroscopic methods, the structures of compounds 1Expand
A novel aryltetralone lignan from Litsea pedunculata
  • L. Wang, J. Zhao, +4 authors Liang Li
  • Chemistry, Medicine
  • Journal of Asian natural products research
  • 6 November 2009
TLDR
A novel aryltetralone lignan was isolated from the leaves and twigs of Litsea pedunculata and the structure was elucidated on the basis of spectroscopic methods and single-crystal X-ray diffraction. Expand
Potent aromatase inhibitors and molecular mechanism of inhibitory action.
TLDR
A combination of experimental and computational approaches facilitates us to understand the molecular mechanism of inhibitory action and discover more potent non-steroidal AIs against aromatase, thereby opening up a novel therapeutic strategy for hormone-dependent breast cancer. Expand
Synthesis and cytotoxic activities of novel phenacylimidazolium bromides.
A series of novel phenacylimidazolium derivatives, bearing an aryl or alkyl substituent at position-1 and a phenacyl substituent at position-3 of the imidazole ring, has been prepared and evaluatedExpand
Oxidative carbon-carbon bond formation in the synthesis of bioactive spiro beta-lactams.
TLDR
By a variation of the oxidative reaction conditions, the usefulness of phenolic amides, derived from 4-aminophenol, in the synthesis of structurally different types of molecules was demonstrated. Expand
Synthesis and cytotoxic activities of novel hybrid compounds of imidazole scaffold-based 2-substituted benzofurans
A series of novel hybrid compounds between 2-substituted benzofuran and imidazole have been prepared and evaluated in vitro against a panel of human tumor cell lines. The results show that the hybridExpand
Solvent-free, microwave assisted synthesis of polyhalo heterocyclic ketene aminals as novel anti-cancer agents.
TLDR
Ethoxycarbonyl substituted 5o, bearing three fluorine atoms on the isophthalonitrile ring, was found to be the most potent derivative with IC(50) values lower than 3.7microg/mL against five human tumor cell lines making it more active than cisplatin (DDP). Expand
Four new phenanthrenes from Monomeria barbata Lindl.
TLDR
Four new biphenanthrene compounds isolated from the tubers of Monomeria barbata Lindl exhibited significant cytotoxic activity against HepG-2 and HL60 cell lines, and potent antioxidant activity in DPPH radical scavenging. Expand
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