Xiangge He

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Pterygium is a type of benign uncontrolled growth of the conjunctive tissue that lays over the sclera. It can significantly alter visual function in advanced cases and become inflamed, leading to redness and irritation in the area. Although the exact etiology of pterygium remains uncertain, recent advances have provided important insight into the(More)
Primary open angle glaucoma (POAG) is characterized by optic disc cupping and irreversible loss of retinal ganglion cells. Few genes have been detected that influence POAG susceptibility and little is known about its genetic architecture. In this study, we employed exome sequencing on three members from a high frequency POAG family to identify the risk(More)
PURPOSE To study the clinical features and to perform genetic linkage study in two large Chinese families with autosomal dominant juvenile-onset primary open-angle glaucoma (POAG). METHODS Eighteen members of one Chinese family and 25 members of a second Chinese family with juvenile-onset primary open-angle glaucoma (POAG) were investigated. Thirteen(More)
BACKGROUND The aim was to review all published studies that investigated the association between MYOC.mt1 polymorphism and the risk of primary open-angle glaucoma (POAG). MATERIAL/METHODS Electronic databases were searched for relevant articles in English. Inclusion and exclusion criteria were established according to the criteria of the Cochrane Methods(More)
OBJECTIVE To compare the efficacy and safety of loteprednol etabonate 0.5%/tobramycin 0.3% (LE/T) and dexamethasone 0.1%/tobramycin 0.3% (DM/T) ophthalmic suspensions in a Chinese population with ocular inflammation associated with blepharokeratoconjunctivitis (BKC). RESEARCH DESIGN AND METHODS This study was a multicenter, randomized,(More)
PURPOSE Primary open-angle glaucoma (POAG) is one of the leading causes of irreversible blindness in the world. To make progress in understanding POAG, it is necessary to identify more POAG-causing genes. METHODS Using haplotype analysis, we found that mutational region is located on chromosome 2 in two families. Furthermore, we screened 11 candidate(More)
OBJECTIVE To confirm the non-inferiority of the IOP-lowering effect of the 0.0015% Tafluprost ophthalmic solution to the 0.005% Latanoprost ophthalmic solution in patients with primary open-angle glaucoma or ocular hypertension.Safety was also compared between two groups. METHODS This study was conducted from August 2008 to December 2009, at five clinical(More)
We demonstrate a novel type of distributed optical fiber acoustic sensor, with the ability to detect and retrieve actual temporal waveforms of multiple vibration events that occur simultaneously at different positions along the fiber. The system is realized via a dual-pulse phase-sensitive optical time-domain reflectometry, and the actual waveform is(More)
PURPOSE To analyze the relationship of the intraocular pressure (IOP), central corneal thickness (CCT) and corneal ectasia in rabbits underwent laser in-situ keratomileusis (LASIK). METHODS This random study comprised three groups: twenty-eight eyes of white rabbits underwent-3D to -10D myopic LASIK, twelve eyes underwent 3D to 10D myopic LASIK, twelve(More)
PURPOSE Use immunohistochemical staining and Western Blot analysis to observe and compare the accurate dynamic changes of type I, III, V, VI collagen in the wound healing processes of the rabbit cornea which underwent LASEK or PRK to investigate the possible mechanism of corneal haze and myopic regression. METHODS New Zealand White rabbits were divided(More)