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CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer
Long non-coding RNA (lncRNA), highly up-regulated in liver cancer (HULC) plays an important role in tumorigenesis. Depletion of HULC resulted in a significant deregulation of several genes involvedExpand
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  • Open Access
NF-kappaB P50/P65 hetero-dimer mediates differential regulation of CD166/ALCAM expression via interaction with micoRNA-9 after serum deprivation, providing evidence for a novel negative
CD166/ALCAM plays an important role in tumor aggression and progression as well as protecting cancer cells against apoptosis and autophagy. However, the mechanism by which pro-cell death signalsExpand
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  • Open Access
The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis
O-GlcNAcylation has been implicated in the tumorigenesis of various tissue origins, but its function in liver tumorigenesis is not clear. Here, we demonstrate that O-GlcNAcylation can enhance theExpand
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SP1 plays a pivotal role for basal activity of TIGAR promoter in liver cancer cell lines
TIGAR expression resulted in down-regulation of glycolysis, reduction of intracellular levels of reactive oxygen species, and protection from apoptosis. Despite biological importance, its promoterExpand
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SIRT1 increases YAP- and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma
Both oncoprotein and tumor-suppressor activity have been reported for SIRTUIN1 (SIRT1) and p38 in many types of cancer. The effect of SIRT1 on p38 phosphorylation (p-p38) remains controversial andExpand
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New Insights into FAK Phosphorylation Based on a FAT Domain-Defective Mutation
Mounting evidence suggests that the FAK N-terminal (FERM) domain controls FAK phosphorylation and function; however, little is known regarding the role of the C terminal (FAT) domain in FAKExpand
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  • Open Access
miR‐598 inhibits metastasis in colorectal cancer by suppressing JAG1/Notch2 pathway stimulating EMT
ABSTRACT MicroRNAs (miRNAs) are a class of endogenous, evolutionarily conserved small non‐coding RNA molecules that mediate the posttranscriptional process of target gene, leading to translationalExpand
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Association of three common BARD1 variants with cancer susceptibility: a system review and meta-analysis.
BARD1 has been shown to play tumor suppressive roles in human cancer. We performed this meta-analysis and firstly evaluated the association between three common BARD1 polymorphisms (Arg378Ser,Expand
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  • Open Access
SP1 is required for basal activation and chromatin accessibility of CD151 promoter in liver cancer cells.
CD151 plays an important role in liver cancer metastasis. The mechanism on how CD151 is expressed remains unclear. Here we have identified SP1 is a protein functioning in constitutive activation ofExpand
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TFCP2 Is Required for YAP-Dependent Transcription to Stimulate Liver Malignancy.
Although YAP-dependent transcription is closely associated with liver tumorigenesis, the mechanism by which YAP maintains its function is poorly understood. Here, we show that TFCP2 is required forExpand
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