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CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer
Long non-coding RNA (lncRNA), highly up-regulated in liver cancer (HULC) plays an important role in tumorigenesis. Depletion of HULC resulted in a significant deregulation of several genes involved… Expand
NF-kappaB P50/P65 hetero-dimer mediates differential regulation of CD166/ALCAM expression via interaction with micoRNA-9 after serum deprivation, providing evidence for a novel negative…
CD166/ALCAM plays an important role in tumor aggression and progression as well as protecting cancer cells against apoptosis and autophagy. However, the mechanism by which pro-cell death signals… Expand
The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis
O-GlcNAcylation has been implicated in the tumorigenesis of various tissue origins, but its function in liver tumorigenesis is not clear. Here, we demonstrate that O-GlcNAcylation can enhance the… Expand
SP1 plays a pivotal role for basal activity of TIGAR promoter in liver cancer cell lines
- Shubiao Zou, Zhidong Gu, P. Ni, Xiangfan Liu, J. Wang, Qishi Fan
- Biology, Medicine
- Molecular and Cellular Biochemistry
TIGAR expression resulted in down-regulation of glycolysis, reduction of intracellular levels of reactive oxygen species, and protection from apoptosis. Despite biological importance, its promoter… Expand
SIRT1 increases YAP- and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma
Both oncoprotein and tumor-suppressor activity have been reported for SIRTUIN1 (SIRT1) and p38 in many types of cancer. The effect of SIRT1 on p38 phosphorylation (p-p38) remains controversial and… Expand
New Insights into FAK Phosphorylation Based on a FAT Domain-Defective Mutation
Mounting evidence suggests that the FAK N-terminal (FERM) domain controls FAK phosphorylation and function; however, little is known regarding the role of the C terminal (FAT) domain in FAK… Expand
miR‐598 inhibits metastasis in colorectal cancer by suppressing JAG1/Notch2 pathway stimulating EMT
ABSTRACT MicroRNAs (miRNAs) are a class of endogenous, evolutionarily conserved small non‐coding RNA molecules that mediate the posttranscriptional process of target gene, leading to translational… Expand
Association of three common BARD1 variants with cancer susceptibility: a system review and meta-analysis.
- Xiangfan Liu, X. Zhang, Y. Chen, X. Yang, Y. C. Xing, L. Ma
- International journal of clinical and…
- 15 January 2015
BARD1 has been shown to play tumor suppressive roles in human cancer. We performed this meta-analysis and firstly evaluated the association between three common BARD1 polymorphisms (Arg378Ser,… Expand
SP1 is required for basal activation and chromatin accessibility of CD151 promoter in liver cancer cells.
- J. Wang, Xiangfan Liu, P. Ni, Zhidong Gu, Qishi Fan
- Medicine, Biology
- Biochemical and biophysical research…
- 5 March 2010
CD151 plays an important role in liver cancer metastasis. The mechanism on how CD151 is expressed remains unclear. Here we have identified SP1 is a protein functioning in constitutive activation of… Expand
TFCP2 Is Required for YAP-Dependent Transcription to Stimulate Liver Malignancy.
Although YAP-dependent transcription is closely associated with liver tumorigenesis, the mechanism by which YAP maintains its function is poorly understood. Here, we show that TFCP2 is required for… Expand