Xiangcai Ruan

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BACKGROUND Dexmedetomidine-induced bradycardia or hypotension has recently attracted considerable attention because of potentially grave consequences, including sinus arrest and refractory cardiogenic shock. A route other than intravenous injection or a low dose may help minimize cardiovascular risks associated with dexmedetomidine. However, few studies(More)
Although tissue-derived high mobility group box 1 (HMGB1) is involved in many aspects of inflammation and tissue injury after trauma, its role in trauma-induced immune suppression remains elusive. Using an established mouse model of peripheral tissue trauma, which includes soft tissue and fracture components, we report here that treatment with anti-HMGB1(More)
BACKGROUND Intranasal dexmedetomidine, a well-tolerated and convenient treatment option, has been shown to induce a favorable perioperative anxiolysis in children. We investigate intranasal dexmedetomidine as a sedative premedication for anesthesia recovery in an adult population. METHODS A prospective randomized controlled trial; 81 adult patients(More)
Inhibition of p-glycoprotein under hyperglycemic conditions has been reported in various barrier tissues including blood-brain barrier, intestine, and kidney, and has been linked to significant clinical complications. However, whether this is also true for the outer blood-retinal barrier constituted by retinal pigment epithelium, or has a role in(More)
PURPOSE To investigate whether dexamethasone has an effect on functional expression of p-glycoprotein in cultured human RPE and, if so, whether this occurs through interaction with glucocorticoid receptor (GR) and pregnane X receptor (PXR). METHODS The human RPE D407 was treated with increasing concentrations of dexamethasone and/or RU486 for various time(More)
Theoretical and experimental investigation have been made on a method called the second reciprocal derivative constant-current stripping analysis (SRD-CCSA). The SRD-CCSA is based on the measurement of the d(2)t/dE(2) signal given by the curve of (d(2)t/dE(2)) versus the electrode potential (E). The d(2)t/dE(2)-E curve gives a maximum value(More)
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