Xiangbao Meng

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Design, Synthesis and Antifibrotic Activities of Carbohydrate- Modified 1-(Substituted aryl)-5-trifluoromethyl-2(1H) Pyridones

Qinghua Lou, Xiangbao Meng, +7 authors Zhongjun Li
Molecules
2012

Pirfenidone, a pyridone compound, is an effective and novel antifibrotic agent. In this article, we describe the design, synthesis and activity evaluation of novel antifibrotic agents, 1-(substituted… (More)

Isorhamnetin Protects against Doxorubicin-Induced Cardiotoxicity In Vivo and In Vitro

Jing Sun, Guibo Sun, +8 authors Xiaobo Sun
PloS one
2013

Doxorubicin (Dox) is an anthracycline antibiotic for cancer therapy with limited usage due to cardiotoxicity. Isorhamnetin is a nature antioxidant with obvious cardiac protective effect. The aim of… (More)

Attenuation of Aβ25-35-induced parallel autophagic and apoptotic cell death by gypenoside XVII through the estrogen receptor-dependent activation of Nrf2/ARE pathways.

Xiangbao Meng, Min Wang, +6 authors Xiaobo Sun
Toxicology and applied pharmacology
2014

Amyloid-beta (Aβ) has a pivotal function in the pathogenesis of Alzheimer's disease. To investigate Aβ neurotoxicity, we used an in vitro model that involves Aβ25-35-induced cell death in the nerve… (More)

Myricitrin Protects against Doxorubicin-Induced Cardiotoxicity by Counteracting Oxidative Stress and Inhibiting Mitochondrial Apoptosis via ERK/P53 Pathway

Jing Sun, Guibo Sun, Xiaolan Cui, Xiangbao Meng, Meng Qin, Xiaobo Sun
Evidence-based complementary and alternative…
2016

Doxorubicin (Dox) is one of the most effective and widely used anthracycline antineoplastic antibiotics. Unfortunately, the use of Dox is limited by its cumulative and dose-dependent cardiac… (More)

Synthesis and structure-activity relationship of 4-azaheterocycle benzenesulfonamide derivatives as new microtubule-targeting agents.

Jun Yang, Shanshan Zhou, +4 authors Xiangbao Meng
Bioorganic & medicinal chemistry letters
2014

A series of 1-sulfonyl indolines was synthesized and evaluated for antiproliferative activity. The most potent compounds 9 a and 9 e showed significant cytotoxicity (IC50 in the range of 0.055-0.105… (More)

Notoginsenoside R1 ameliorates diabetic encephalopathy by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation

Yadong Zhai, Xiangbao Meng, +9 authors Xiaobo Sun
Oncotarget
2018

Numerous researches supported that oxidative stress and inflammation play important roles in the development of diabetic encephalopathy (DEP). Notoginsenoside R1 (NGR1), one major component of Panax… (More)

Ginsenoside RK3 Prevents Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes via AKT and MAPK Pathway

Jing Sun, Guibo Sun, +9 authors Xiaobo Sun
Evidence-based complementary and alternative…
2013

Reperfusion therapy is widely utilized for acute myocardial infarction (AMI), but further injury induced by rapidly initiating reperfusion of the heart is often encountered in clinical practice.… (More)

Notoginsenoside R1 attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation.

Bo Ma, Xiangbao Meng, +6 authors Xiaobo Sun
International immunopharmacology
2014

Progressive accumulation of amyloid-β (Aβ) is a pathological hallmark of Alzheimer's disease (AD). Aβ increases free radical production in neuronal cells, leading to oxidative stress and cell death.… (More)

Gypenoside XVII Enhances Lysosome Biogenesis and Autophagy Flux and Accelerates Autophagic Clearance of Amyloid-β through TFEB Activation.

Xiangbao Meng, Yun Luo, +4 authors Xiaobo Sun
Journal of Alzheimer's disease : JAD
2016

A strategy for activating transcription factor EB (TFEB) to restore autophagy flux may provide neuroprotection against Alzheimer's disease. Our previous study reported that gypenoside XVII (GP-17),… (More)

BF3·OEt2-promoted diastereoselective diacetoxylation of alkenes by PhI(OAc)2.

Wenhe Zhong, Jun Yang, Xiangbao Meng, Zhongjun Li
The Journal of organic chemistry
2011

Selective syn and anti diacetoxylations of alkenes have been achieved using a PhI(OAc)(2)/BF(3)·OEt(2) system in the presence and absence of water, respectively. A broad range of substrates including… (More)

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