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d‐DOPA IS UNIDIRECTIONALLY CONVERTED TO l‐DOPA BY d‐AMINO ACID OXIDASE, FOLLOWED BY DOPA TRANSAMINASE
TLDR
Results prove the proposal that d‐dopa undergoes unidirectional chiral inversion and suggest that d•dopa is first oxidatively deaminated by DAAO to its α‐keto acid and then transaminatedBy dopa transaminase to l‐dop.
Spinal d-Amino Acid Oxidase Contributes to Neuropathic Pain in Rats
TLDR
Investigation of the potential role of DAO in neuropathic pain in a rat model of tight L5/L6 spinal nerve ligation concludes that spinal DAO plays a pronociceptive role and might be a target molecule for the treatment of chronic pain of neuropathic origin.
Inhibition of d-Amino-Acid Oxidase Activity Induces Pain Relief in Mice
TLDR
It is suggested that DAO acts as a pro-nociceptive factor in pain, particularly chronic pain, transmission and modulation, and may be a target for pain treatment.
Biological implications of oxidation and unidirectional chiral inversion of D-amino acids.
TLDR
This review provides an overview of recent research in this area, highlighting the indispensable but insufficient role of DAAO particularly in the kidneys and brain for the oxidation and chiral inversion of D-amino acids analogs; and unidentified transaminase(s) responsible for the second step of chiralInversion.
Renal d-Amino Acid Oxidase Mediates Chiral Inversion of NG-Nitro-d-arginine
TLDR
Results reveal a novel pathway of chiral inversion of d-amino acids where the renal DAAO plays an essential role that accounts for the biological activity ofd-NNA.
Histone deacetylation directs DNA methylation in survivin gene silencing.