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Antitussive, expectorant, and anti-inflammatory activities of four caffeoylquinic acids isolated from Tussilago farfara
- Qi-Zhen Wu, Dong‐Xia Zhao, J. Xiang, Mian Zhang, Chaofeng Zhang, Xiang-hong Xu
- MedicinePharmaceutical biology
- 1 July 2016
The caffeoylquinic acids and their mixture, exhibiting significant antitussive, expectorant, and anti-inflammatory effects, could be considered as the main effective ingredients of FTF, and they may act in a collective and synergistic way.
Simultaneous separation and determination of phenolic acids, pentapeptides, and triterpenoid saponins in the root of Aster tataricus by high-performance liquid chromatography coupled with…
- Dong‐Xia Zhao, Bingfeng Hu, Mian Zhang, Chaofeng Zhang, Xiang-hong Xu
- ChemistryJournal of separation science
- 1 February 2015
A reliable method was developed for the simultaneous quantification of 3-caffeoylquinic acid, 3,4-dicaffeoyLquinic Acid,3,5- dicaffeoyslquinIC acid, astin A,Astin B, astIn C, astersaponin A and astersapons C, and the qualified separations were achieved only on a C18 column packed with 2.7 μm particles.
Preventive effects of Ecliptae Herba extract and its component, ecliptasaponin A, on bleomycin-induced pulmonary fibrosis in mice.
Expectorant, antitussive, anti-inflammatory activities and compositional analysis of Aster tataricus.
Immunosuppressive C₂₁ steroidal glycosides from the root of Cynanchum atratum.
Neotuberostemonine inhibits the differentiation of lung fibroblasts into myofibroblasts in mice by regulating HIF-1α signaling
Results demonstrate that NTS inhibits the protein expression of HIF-1α and its downstream factors TGF-β, FGF2 and α-SMA both in hypoxia-exposed fibroblasts and in lung tissues of BLM-treated mice.
Neotuberostemonine attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages.
Astin B, a cyclic pentapeptide from Aster tataricus, induces apoptosis and autophagy in human hepatic L-02 cells.
Pharmacokinetics, biodistribution and excretion studies of neotuberostemonine, a major bioactive alkaloid of Stemona tuberosa.
Stemona alkaloids suppress the positive feedback loop between M2 polarization and fibroblast differentiation by inhibiting JAK2/STAT3 pathway in fibroblasts and CXCR4/PI3K/AKT1 pathway in macrophages.