Xiang-feng Zhang

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Recently, a collective effort from multiple research areas has been made to understand biological systems at the system level. This research requires the ability to simulate particular biological systems as cells, organs, organisms, and communities. In this paper, a novel bio-network simulation platform is proposed for system biology studies by combining(More)
OBJECTIVE To investigate the pathways to cell death in hyperoxia-induced lung injury and the functional significance of apoptosis in vivo in response to hyperoxia. METHODS Seventy-two mice were exposed in sealed cages > 98% oxygen (for 24 - 72 h) or room air, and the severity of lung injury and epithelium sloughing was evaluated. The extent and location(More)
BACKGROUND Obstructive sleep apnea hypopnea syndrome (OSAHS) constitutes an independent factor for high warfarin dose for patients with pulmonary embolism (PE). The aim of this study was to investigate whether the 6-month anticoagulation treatment by warfarin is enough for patients with PE complicated by OSAHS. METHODS We investigated 97 PE patients, 32(More)
OBJECTIVE To describe the clinical features of obstructive sleep apnea-hypopnea syndrome (OSAHS) in hospitalized pulmonary thromboembolism (PTE) patients, and to explore its impact on the severity of disease and management among patients with PTE. METHODS Demographic and clinical characteristics of 28 PTE patients complicated with OSAHS admitted to this(More)
Agent technology and multi-agent theories are widely applied to distributed intelligent control systems. Considering the similarities between an immune system and a multi-agent system, we have proposed an immune agent. The immune agent is an agent with immune mechanisms, such as, cognition, learning, and evolution. And its formalization description is(More)
absTracT Future Internet should be capable of extensibility, survivability, mobility, and adaptability to the changes of different users and network environments, so it is necessary to optimize the current Internet architecture and its applications. Inspired by the resemble features between the immune systems and future Internet, the authors introduce some(More)
BACKGROUND Exposure of adult mice to more than 95% O(2) produces a lethal injury by 72 hours. Nitric oxide synthase (NOS) is thought to contribute to the pathophysiology of murine hyperoxia-induced acute lung injury (ALI). Osteopontin (OPN) is a phosphorylated glycoprotein produced principally by macrophages. OPN inhibits inducible nitric oxide synthase(More)
OBJECTIVE To examine the role of osteopontin (OPN) in hyperoxia-induced acute lung injury (ALI) and its relationships with matrix metalloproteinases (MMP). METHODS Seventy-two OPN gene wild type (OPN(+/+)) mice were divided into normal control group (WN group), hyperoxia for 24 hours group (WO(1) group), hyperoxia for 48 hours group (WO(2) group) and(More)
OBJECTIVE To investigate the role of matrix metalloproteinase-2/9 (MMP-2/9) and their tissue inhibitors (TIMP-1/2) in pathogenesis of acute lung injury (ALI) induced by hyperoxia. METHODS Seventy-two C57BL/6 mice were randomly divided into normal control group, hyperoxia for 24 hours group, hyperoxia for 48 hours group, and hyperoxia for 72 hours group,(More)
Network performance relies on the design of control algorithm and network information scheduling in a networked control system (NCS). The effect of the network scheduling is to allocate rationally network resources and improve network utilization. A scheduling approach is presented to implement the scheduling of a set of periodic tasks in this paper. And an(More)