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APOBEC3G Subunits Self-associate via the C-terminal Deaminase Domain*
Co-immunoprecipitation and in-cell quenched fluorescence resonance energy transfer assays reveal that hA3G forms RNA-independent oligomers through interactions within its C terminus, corroborate the small angle x-ray scattering structural model and are instructive for development of high throughput screens that target specific domains and their functions to identify HIV/AIDS therapeutics.
Identification of a Crucial Residue Required for Staphylococcus aureus LukAB Cytotoxicity and Receptor Recognition
It is reported that leukocidin A/B (LukAB), the most divergent member of the leukotoxin family, exists as a heterodimer in solution rather than two separate monomeric subunits, and this property was found to be associated with enhanced toxin activity.
In Vitro and in Vivo Dimerization of Human Endonuclease III Stimulates Its Activity*
It is demonstrated for the first time that the full-length hNTH1 positively cooperates in product formation as a function of enzyme concentration and masks the inhibitory effect of this tail and plays a critical role in its catalytic turnover in the cell.
Replication-coupled repair of crotonaldehyde/acetaldehyde-induced guanine-guanine interstrand cross-links and their mutagenicity.
One of the current models for the mammalian NER-independent ICL repair mechanism is supported, in which a DNA endonuclease unhooks an ICL from the leading strand template at a stalled replication fork site by incising on both sides of the ICL and then translesion synthesis is conducted across the "half-excised" ICL attached to the lagging strand template to restore DNA synthesis.