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Recent genome-wide screens have highlighted an important role for transportin 3 in human immunodeficiency virus type 1 (HIV-1) infection and preintegration complex (PIC) nuclear import. Moreover, HIV-1 integrase interacted with recombinant transportin 3 protein under conditions whereby Moloney murine leukemia virus (MLV) integrase failed to do so,(More)
Probabilistic logic and credibilistic logic are two branches of multi-valued logic for dealing with random knowledge and fuzzy knowledge, respectively. In this paper, a hybrid logic is introduced for dealing with random knowledge and fuzzy knowledge simultaneously. First, a hybrid formula is introduced on the basis of random proposition and fuzzy(More)
Most existing person re-identification (re-id) models focus on matching still person images across disjoint camera views. Since only limited information can be exploited from still images, it is hard (if not impossible) to overcome the occlusion, pose and camera-view change, and lighting variation problems. In comparison, video-based re-id methods can(More)
Feature representation and metric learning are two critical components in person re-identification models. In this paper, we focus on the feature representation and claim that hand-crafted histogram features can be complementary to Convolutional Neural Network (CNN) features. We propose a novel feature extraction model called Feature Fusion Net (FFN) for(More)
The impact that stressful encounters have upon long-lasting behavioural phenotypes is varied. Whereas a significant proportion of the population will develop "stress-related" conditions such as post-traumatic stress disorder or depression in later life, the majority are considered "resilient" and are able to cope with stress and avoid such(More)
MicroRNAs are small non-coding RNAs that mediate post-transcriptional gene silencing. Fear-extinction learning in C57/Bl6J mice led to increased expression of the brain-specific microRNA miR-128b, which disrupted stability of several plasticity-related target genes and regulated formation of fear-extinction memory. Increased miR-128b activity may therefore(More)
Energetic hot spots account for a significant portion of the total binding free energy and correlate with structurally conserved interface residues. Here, we map experimentally determined hot spots and structurally conserved residues to investigate their geometrical organization. Unfilled pockets are pockets that remain unfilled after protein-protein(More)
Cystic fibrosis (CF) is one of the most frequently diagnosed autosomal-recessive diseases in the Caucasian population. For general-population CF carrier screening, the American College of Medical Genetics (ACMG)/American College of Obstetricians and Gynecologists (ACOG) have recommended a core panel of 23 mutations that will identify 49-98% of carriers,(More)
5-hydroxymethylcytosine (5-hmC) is a novel DNA modification that is highly enriched in the adult brain and dynamically regulated by neural activity. 5-hmC accumulates across the lifespan; however, the functional relevance of this change in 5-hmC and whether it is necessary for behavioral adaptation have not been fully elucidated. Moreover, although the(More)