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High-grade gliomas are difficult to treat. We examined the therapeutic effect of intratumoral administration of human amniotic membrane derived-mesenchymal stem cells (hAMCs) on the growth of gliomas. Tumor volume of the control group was 1632 ± 316 mm3 on day 30, and the group treated with a single intratumoral dose of hAMCs had a tumor volume of 1128 ±(More)
Current treatments for ischemic stroke are limited, stem cell transplantation offers great potential as a therapeutic strategy. The present study was undertaken to determine whether human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) could improve brain injury after middle cerebral artery occlusion (MCAO) through modulating peripheral(More)
AIMS AND BACKGROUND Glioma is difficult to treat and despite advances, outcomes remain poor and new treatment modalities are required. We studied the inhibitive effects of human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) on glioma growth. MATERIAL AND METHODS UCB-MSCs were identified in mice by flow cytometric analysis, and neurogenic(More)
Gait deficits are important clinical symptoms of Parkinson’s disease (PD). However, existing behavioral tests for the detection of motor impairments in rodents with systemic dopamine depletion only measure akinesia and dyskinesia, and data focusing on gait are scarce. We evaluated gait changes in the methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced(More)
Development of reporter genes for multimodality molecular imaging is highly important. In contrast to the conventional strategies which have focused on fusing several reporter genes together to serve as multimodal reporters, human tyrosinase (TYR)--the key enzyme in melanin production--was evaluated in this study as a stand-alone reporter gene for in vitro(More)
BACKGROUND The current paradigm for cord blood transplantation is that HLA matching and immune suppression are strictly required to prevent graft versus host disease (GVHD). Immunological arguments and historical examples have been made that the use of cord blood for non-hematopoietic activities such as growth factor production, stimulation of angiogenesis,(More)
—Power grid verification has become an indispensable step to guarantee a functional and robust chip design. Vectorless power grid verification methods, by solving linear programming (LP) problems under current constraints, enable worst-case voltage drop predictions at an early stage of design when the specific waveforms of current drains are unknown. In(More)
—In this paper, an efficient framework is proposed to analyze the worst case of voltage variation of power network considering multidomain clock gating. First, a frequency-domain-based simulation method is proposed to obtain the time-domain voltage response. With the vector fitting technique, the frequency-domain responses are approximated by a partial(More)