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—This paper studies an important problem in the IEEE 802.11 distributed coordination function (DCF)-based wireless local area network (WLAN): how well can the network support quality of service (QoS). Specifically, this paper analyzes the network's performance in terms of maximum protocol capacity or throughput, delay, and packet loss rate. Although the(More)
— In the emerging IEEE 802.11e MAC protocol, the Enhanced Distributed Channel Access (EDCA) is proposed to support prioritized QoS; however, it cannot guarantee strict QoS required by real-time services such as voice and video without proper network control mechanisms. To overcome this deficiency, we first build an analytical model to derive an average(More)
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases and assessed the frequency of the identified somatic mutations in 94 T-cell acute lymphoblastic leukaemia cases. ETP ALL was characterized by activating mutations in genes regulating(More)
The presence of DNA in the cytoplasm of mammalian cells is a danger signal that triggers host immune responses such as the production of type I interferons. Cytosolic DNA induces interferons through the production of cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP), which binds to and activates the adaptor protein STING.(More)
Cytosolic DNA induces type I interferons and other cytokines that are important for antimicrobial defense but can also result in autoimmunity. This DNA signaling pathway requires the adaptor protein STING and the transcription factor IRF3, but the mechanism of DNA sensing is unclear. We found that mammalian cytosolic extracts synthesized cyclic guanosine(More)
In this paper, we proposed a novel call admission and rate control (CARC) scheme. Unlike previous research works that are focused on providing service differentiation in the contention-based 802.11 DCF, we aim to support stringent QoS requirements of real-time and streaming traffic. The key idea of this scheme is to regulate the arriving traffic of the WLAN(More)
Pediatric high-grade glioma (HGG) is a devastating disease with a less than 20% survival rate 2 years after diagnosis. We analyzed 127 pediatric HGGs, including diffuse intrinsic pontine gliomas (DIPGs) and non-brainstem HGGs (NBS-HGGs), by whole-genome, whole-exome and/or transcriptome sequencing. We identified recurrent somatic mutations in ACVR1(More)
Proteasomal receptors that recognize ubiquitin chains attached to substrates are key mediators of selective protein degradation in eukaryotes. Here we report the identification of a new ubiquitin receptor, Rpn13/ARM1, a known component of the proteasome. Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for(More)
Mobile ad hoc networks (MANETs) are useful in environment where fixed network infrastructure is unavailable. To function normally, MANETs demand an efficient and distributed medium access control (MAC) protocol. However, characteristics of MANETs such as radio link vulnerability, mobility, limited power pose great challenges on MAC design. This paper(More)
In this papel; we focus on the problems from interaction between the congestion of traficfZows and the MAC layer contentions for reliable service, say TCP trafiic. We first characterize the interaction as intra-$ow contention and inter-$ow contention and illustrate their severe impact on the performance of MANET. Then we propose a novel distributed scheme(More)