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—This paper studies an important problem in the IEEE 802.11 distributed coordination function (DCF)-based wireless local area network (WLAN): how well can the network support quality of service (QoS). Specifically, this paper analyzes the network's performance in terms of maximum protocol capacity or throughput, delay, and packet loss rate. Although the(More)
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases and assessed the frequency of the identified somatic mutations in 94 T-cell acute lymphoblastic leukaemia cases. ETP ALL was characterized by activating mutations in genes regulating(More)
Cytosolic DNA induces type I interferons and other cytokines that are important for antimicrobial defense but can also result in autoimmunity. This DNA signaling pathway requires the adaptor protein STING and the transcription factor IRF3, but the mechanism of DNA sensing is unclear. We found that mammalian cytosolic extracts synthesized cyclic guanosine(More)
— In the emerging IEEE 802.11e MAC protocol, the Enhanced Distributed Channel Access (EDCA) is proposed to support prioritized QoS; however, it cannot guarantee strict QoS required by real-time services such as voice and video without proper network control mechanisms. To overcome this deficiency, we first build an analytical model to derive an average(More)
The presence of DNA in the cytoplasm of mammalian cells is a danger signal that triggers host immune responses such as the production of type I interferons. Cytosolic DNA induces interferons through the production of cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP), which binds to and activates the adaptor protein STING.(More)
Pediatric high-grade glioma (HGG) is a devastating disease with a less than 20% survival rate 2 years after diagnosis. We analyzed 127 pediatric HGGs, including diffuse intrinsic pontine gliomas (DIPGs) and non-brainstem HGGs (NBS-HGGs), by whole-genome, whole-exome and/or transcriptome sequencing. We identified recurrent somatic mutations in ACVR1(More)
In this paper, we proposed a novel call admission and rate control (CARC) scheme. Unlike previous research works that are focused on providing service differentiation in the contention-based 802.11 DCF, we aim to support stringent QoS requirements of real-time and streaming traffic. The key idea of this scheme is to regulate the arriving traffic of the WLAN(More)
The most common pediatric brain tumors are low-grade gliomas (LGGs). We used whole-genome sequencing to identify multiple new genetic alterations involving BRAF, RAF1, FGFR1, MYB, MYBL1 and genes with histone-related functions, including H3F3A and ATRX, in 39 LGGs and low-grade glioneuronal tumors (LGGNTs). Only a single non-silent somatic alteration was(More)
Proteasomal receptors that recognize ubiquitin chains attached to substrates are key mediators of selective protein degradation in eukaryotes. Here we report the identification of a new ubiquitin receptor, Rpn13/ARM1, a known component of the proteasome. Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for(More)
Mobile ad hoc networks (MANETs) are useful in environment where fixed network infrastructure is unavailable. To function normally, MANETs demand an efficient and distributed medium access control (MAC) protocol. However, characteristics of MANETs such as radio link vulnerability, mobility, limited power pose great challenges on MAC design. This paper(More)