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Tubulin is known to undergo unique post-translational modifications (PTMs), such as detyrosination and polyglutamylation, particularly in the unstructured carboxy-terminal tails (CTTs). However, more conventional PTMs of tubulin and their roles in the regulation of microtubule properties and functions remain poorly defined. Here, we report the comprehensive(More)
A full-scale seven-story reinforced concrete building section was tested on the UCSDNEES shake table during the period October 2005 January 2006. The shake table tests were designed to damage the building progressively through four historical earthquake records. At various levels of damage, ambient vibration tests and low amplitude white noise base(More)
The damage identification study presented in this article leveraged a full-scale sub-component experiment conducted in the Charles Lee P owell Structural Research Laboratories at the University of California, San Diego. As a payload project attached to a quasi-static test of a full-scale composite beam, a high-quality set of lowamplitude vibration response(More)
In this article, wind-induced vibration response of Vincent Thomas Bridge, a suspension bridge located in San Pedro near LosAngeles, California, is simulated using a detailed three-dimensional finite element model of the bridge and a state-of-the-art stochastic wind excitation model. Based on the simulated wind-induced vibration data, the modal parameters(More)
The innate immune system is the first line of host defense against infection and involves several different cell types. Here we investigated the role of the phosphatidylinositol 3 kinase (PI3K) signaling pathway in innate immune cells. By blocking this pathway with pharmacological inhibitors, we found that the production of proinflammatory cytokines was(More)
Neuroblastoma is one of the most prevalent pediatric extracranial solid tumors and is often diagnosed after dissemination has occurred. Despite recent advances in multimodal therapies of this malignancy, its therapeutic efficacy remains poor. Novel treatment strategies are thus in great need. Herein, we demonstrate that histone deacetylase 6 (HDAC6), a(More)
OBJECTIVE Atherosclerosis and other cardiovascular diseases are serious threats to human health and become the leading cause of death in the world. Emerging evidence reveals that inhibition of plaque neovascularization could be an effective approach for the treatment of atherosclerosis. This study was conducted to identify cytoplasmic linker protein 170 as(More)
Microtubule-binding proteins (MBPs) are structurally and functionally diverse regulators of microtubule-mediated cellular processes. Alteration of MBPs has been implicated in the pathogenesis of human diseases, including cancer. MBPs can stabilize or destabilize microtubules or move along microtubules to transport various cargoes. In addition, MBPs can(More)
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