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DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells*
TLDR
The findings offer new insights on the mechanisms of ER stress-mediated apoptosis and highlight novel mechanisms underlying endoplasmic reticulum stress-induced TNFRSF10A and TNF RSF10B expressions and apoptosis.
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Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells
TLDR
It is demonstrated here that chaetocin effectively suppressed the growth of multiple lung cancer cells through inducing apoptosis in a death receptor 5 (DR5)-dependent manner and provides a novel interpretation on the anti-neoplastic activity of epigenetic drugs as a new therapeutic approach in NSCLC.
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MicroR-140-5p suppresses tumor cell migration and invasion by targeting ADAM10-mediated Notch1 signaling pathway in hypopharyngeal squamous cell carcinoma.
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Cordycepin induces autophagy-mediated c-FLIPL degradation and leads to apoptosis in human non-small cell lung cancer cells
TLDR
It is shown that cordycepin induces apoptosis through autophagy-mediated downregulation of c-FLIPL in human NSCLC cells, providing a novel prospect on the anti-tumor property of Cordyceps militaris.
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A novel derivative of tetrandrine (H1) induces endoplasmic reticulum stress-mediated apoptosis and prosurvival autophagy in human non-small cell lung cancer cells
TLDR
It is suggested that H1 induces DR5-dependent apoptosis in human NSCLC cells via stimulating ER stress signaling pathway, and pharmacologically inhibiting autophagy will be an efficient approach to synergize H1-caused apoptosisIn lung cancer cells.
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Afatinib down-regulates MCL-1 expression through the PERK-eIF2α-ATF4 axis and leads to apoptosis in head and neck squamous cell carcinoma.
TLDR
The results show that afatinib hampers AKT-mTOR activation by stimulating PERK-eIF2α-ATF4 signaling pathway, giving rise to MCL-1 down-regulation mediated apoptosis in HNSCC cells.
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Upregulation of fascin-1 is involved in HIF-1α-dependent invasion and migration of hypopharyngeal squamous cell carcinoma
TLDR
Fascin-1 was upregulated by HIF-1α, and promoted the invasion and migration of HSCC cells; therefore, fascin- 1 may provide a potential target for the treatment of invasion and metastasis in HSCC.
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Methyl jasmonate induces apoptosis and pro-apoptotic autophagy via the ROS pathway in human non-small cell lung cancer.
TLDR
It is found that MJ triggered apoptosis via the DDIT3-TNFRSF10B-CASP axis and inhibition of ROS suppressed both MJ-induced apoptosis and autophagy and may serve as a novel chemotherapeutic strategy for cancer therapy.
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Loss of CDH1 up‐regulates epidermal growth factor receptor via phosphorylation of YBX1 in non‐small cell lung cancer cells
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Elevated AEG-1 expression in macrophages promotes hypopharyngeal cancer invasion through the STAT3-MMP-9 signaling pathway
TLDR
It is demonstrated that macrophage AEG-1 promotes tumor invasion through up-regulation of MMP-9 in both macrophages and cancer cells, and represents as a potential target in hypopharyngeal cancer therapy.
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