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Resveratrol inhibits VEGF‐induced angiogenesis in human endothelial cells associated with suppression of aerobic glycolysis via modulation of PKM2 nuclear translocation
Endothelial cells (ECs) mainly depend on aerobic glycolysis to generate angiogenesis. Deregulation of glycolysis is often observed in human endothelial cells during angiogenesis. In the presentExpand
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Quercetin stimulates mitochondrial apoptosis dependent on activation of endoplasmic reticulum stress in hepatic stellate cells
Abstract Context: Activation of hepatic stellate cells (HSCs) is a hallmark of liver fibrosis. Quercetin has benefits for liver fibrosis, but the mechanisms are unknown. Objective: We investigatedExpand
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Nuclear PKM2 expression, an independent risk factor for ER after curative resection of hepatocellular carcinoma.
Surgical resection, providing a long-term survival of hepatocellular carcinoma (HCC) patients, is regarded as one of the standard curative treatments of HCC if the tumor is resectable. However, 50%Expand
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Resveratrol suppresses pulmonary tumor metastasis by inhibiting platelet-mediated angiogenic responses.
BACKGROUND To explore the impact of Resveratrol (RSV) on the angiogenic potential of activated platelets and to elucidate the underlying mechanism. METHODS Vascular endothelial growth factorExpand
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4(3H)‐Quinazolone regulates innate immune signaling upon respiratory syncytial virus infection by moderately inhibiting the RIG‐1 pathway in RAW264.7 cell
ABSTRACT The root of Isatis indigotica, also known as Ban‐Lan‐Gen (BLG), is commonly used for prevention and early treatment of respiratory virus infection, but the underlying mechanisms of actionExpand
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Different types of effective fractions from Radix Isatidis revealed a multiple-target synergy effect against respiratory syncytial virus through RIG-I and MDA5 signaling pathways, a pilot study to
ETHNOPHARMACOLOGICAL RELEVANCE Radix Isatidis, a commonly used traditional Chinese medicine, is also documented in "Dictionary of Chinese Ethnic Medicine" being as an ethnic herb clinically utilizedExpand
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Indole-3-carboxaldehyde regulates RSV-induced inflammatory response in RAW264.7 cells by moderate inhibition of the TLR7 signaling pathway.
Human respiratory syncytial virus (RSV) is highly contagious and the leading cause of severe respiratory tract illness in infants, elderly, and immunocompromised individuals. Toll-like receptor 7Expand