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Resveratrol inhibits VEGF‐induced angiogenesis in human endothelial cells associated with suppression of aerobic glycolysis via modulation of PKM2 nuclear translocation
- Hongyan Wu, Liwei He, +5 authors Fang-tian Fan
- Chemistry, Medicine
- Clinical and experimental pharmacology…
- 1 December 2018
Endothelial cells (ECs) mainly depend on aerobic glycolysis to generate angiogenesis. Deregulation of glycolysis is often observed in human endothelial cells during angiogenesis. In the present… Expand
Quercetin stimulates mitochondrial apoptosis dependent on activation of endoplasmic reticulum stress in hepatic stellate cells
Abstract Context: Activation of hepatic stellate cells (HSCs) is a hallmark of liver fibrosis. Quercetin has benefits for liver fibrosis, but the mechanisms are unknown. Objective: We investigated… Expand
Nuclear PKM2 expression, an independent risk factor for ER after curative resection of hepatocellular carcinoma.
- Fang-tian Fan, Hongyan Wu, +4 authors Yin Lu
- Biomedicine & pharmacotherapy = Biomedecine…
- 1 December 2016
Surgical resection, providing a long-term survival of hepatocellular carcinoma (HCC) patients, is regarded as one of the standard curative treatments of HCC if the tumor is resectable. However, 50%… Expand
Resveratrol suppresses pulmonary tumor metastasis by inhibiting platelet-mediated angiogenic responses.
- L. He, Fang-tian Fan, +5 authors Hongyan Wu
- Biology, Medicine
- The Journal of surgical research
- 1 September 2017
BACKGROUND To explore the impact of Resveratrol (RSV) on the angiogenic potential of activated platelets and to elucidate the underlying mechanism. METHODS Vascular endothelial growth factor… Expand
4(3H)‐Quinazolone regulates innate immune signaling upon respiratory syncytial virus infection by moderately inhibiting the RIG‐1 pathway in RAW264.7 cell
- L. He, Fang-tian Fan, +4 authors Y. Sun
- Biology, Medicine
- International immunopharmacology
- 1 November 2017
ABSTRACT The root of Isatis indigotica, also known as Ban‐Lan‐Gen (BLG), is commonly used for prevention and early treatment of respiratory virus infection, but the underlying mechanisms of action… Expand
Different types of effective fractions from Radix Isatidis revealed a multiple-target synergy effect against respiratory syncytial virus through RIG-I and MDA5 signaling pathways, a pilot study to…
ETHNOPHARMACOLOGICAL RELEVANCE Radix Isatidis, a commonly used traditional Chinese medicine, is also documented in "Dictionary of Chinese Ethnic Medicine" being as an ethnic herb clinically utilized… Expand
Indole-3-carboxaldehyde regulates RSV-induced inflammatory response in RAW264.7 cells by moderate inhibition of the TLR7 signaling pathway.
- Xianbang Hou, Xueyuan Zhang, Jingting Bi, Anhong Zhu, Liwei He
- Journal of natural medicines
- 23 March 2021
Human respiratory syncytial virus (RSV) is highly contagious and the leading cause of severe respiratory tract illness in infants, elderly, and immunocompromised individuals. Toll-like receptor 7… Expand