Xian-pei Wang

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AbstractAim:The objectives of this study were to investigate the inhibitory action of verapamil on wild-type(WT) and mutation HERG K+ channel current (IHERG), and to determine whether mutations in the S6 region are important for the inhibition of IHERG by verapamil.Methods:HERG channels (WT, Y652A, and F656A) were expressed in oocytes of Xenopus laevis and(More)
OBJECTIVE Considerable evidence suggests that thyroid dysfunction, especially hypothyroidism, may lead to coronary artery disease (CAD). The aim of this study is to investigate the effect of low serum levels of free triiodothyronine (FT3) on coronary artery calcification in outpatients with suspected CAD and the occurrence rate of major adverse cardiac(More)
Magnetic field inhomogeneity is a long-standing problem in magnetic resonance imaging (MRI) and spectroscopic imaging (MRSI). Specifically, in MRSI, field inhomogeneity, if not corrected, can cause frequency shifts, line broadening, and lineshape distortions in the spectral peaks. This paper addresses the problem of correcting the field inhomogeneity(More)
Compressive sensing (CS) MRI aims to accurately reconstruct images from undersampled k-space data. Most CS methods employ analytical sparsifying transforms such as total-variation and wavelets to model the unknown image and constrain the solution space during reconstruction. Recently, nonparametric dictionary-based methods for CS-MRI reconstruction have(More)
The safety and efficacy of rivaroxaban in the periprocedural anticoagulation for patients undergoing catheter ablation of atrial fibrillation is not well established. We sought to systematically review this evidence using data from multiple studies. A thorough literature search was conducted in MEDLINE, EMABSE, Web of knowledge, clinicaltrials.gov, and the(More)
Backgroud and objective Plaque rupture, platelet aggregation, and thrombogenesis are the main mechanisms of acute coronary syndrome (ACS), and inflammation factors play key roles in plaque unstability. Psychological stress promotes acute inflammatory response, leading to increased circulating levels of C-reactive protein (CRP), IL-6, and serum intercellular(More)
BACKGROUND/AIMS After myocardial infarction (MI), cardiac fibrosis greatly contributes to left ventricular remodeling and heart failure. The intermediate-conductance calcium-activated potassium Channel (KCa3.1) has been recently proposed as an attractive target of fibrosis. The present study aimed to detect the effects of KCa3.1 blockade on ventricular(More)
OBJECTIVES This study aimed to survey the adherence to smoking cessation and assess the influence of persistent smoking on the prognosis in male patients after drug-eluting stent (DES) implantation. METHODS The smoking status at the time of the index procedure and at follow-up was surveyed in 656 male patients undergoing successful percutaneous coronary(More)
BACKGROUND Tissue factor (TF) is the initiation factor of the extrinsic coagulation pathway, and plays a critical role in the process of thrombosis. This study aimed to investigate the expression of TF and to explore their clinical effect on the pulmonary artery after acute pulmonary thromboembolism. METHODS Thirty-four Japanese white rabbits (Level II(More)
Background Warfarin is efficacious for ischemic stroke prevention in intermediate- to high-risk patients with atrial fibrillation; thus, warfarin is the recommended treatment according to evidence-based guidelines. Objective This prospective study evaluated the reasons for under-utilization of warfarin in Chinese patients with non-valvular atrial(More)