Xian Yu

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MicroRNA (miR)-155 is a critical player in both innate and adaptive immune responses. It can influence CD4(+) T cell lineage choice. To clarify the role of miR-155 in CD4(+) CD25(+) regulatory T (Treg)/T helper (Th)17 cell differentiation and function, as well as the mechanism involved, we performed gain-and loss-of-function analysis by transfection(More)
In this paper, we propose an improvement on LEACH (Low Energy Adaptive Clustering Hierarchy) protocol in order to monitor the large-scale environment longer and stably with wireless sensor networks. Since being proposed, the LEACH protocol has been regard as a perfect routing protocol of wireless sensor networks (WSNs) while the system was used to monitor(More)
Recent studies have indicated a protective role of physiological autophagy in ischemic heart disease. However, the underlying mechanisms of autophagy regulation after ischemia are poorly understood. Exosomes are nano-sized vesicles released from cells that play critical roles in mediating cell-to-cell communication through the transfer of microRNAs. In this(More)
Recently, our group has developed a therapeutic hypertensive vaccine against angiotensin (Ang) II type 1 receptor (AT1R) named ATRQβ-001. To explore its potential effectiveness on streptozotocin-induced diabetic nephropathy, male Sprague Dawley rats were randomly divided into two groups: a control and a diabetic model. After 1 week, the diabetic rats were(More)
Vaccination provides a promising approach for treatment of hypertension and improvement in compliance. As the initiation factor of renin-angiotensin system, renin plays a critical role in hypertension. In this study, we selected six peptides (rR32, rR72, rR215, hR32, hR72, and hR215) belonging to potential epitopes of rat and human renin. The main criteria(More)
Cancer cells with stem cell properties (CSCs) underpin the chemotherapy resistance and high therapeutic failure of triple-negative breast cancers (TNBCs). Even though CSCs are known to proliferate more slowly, they are sensitive to inhibitors of G2/M kinases such as polo-like kinase 1 (PLK1). Understanding the cell cycle regulatory mechanisms of CSCs will(More)
Summary form only given. Named Data Networking (NDN) is an emerging future Internet architecture with an alternative communication paradigm. For NDN, name lookup, just like IP address lookup for TCP/IP, plays an important role in forwarding. However, performing Longest Prefix Matching (LPM) to NDN names is more challenging. Recently, Graphic Processing(More)
Recently, Graphic Processing Units (GPUs) have been shown to be of value in supporting wire-speed name lookup in Named Data Networking (NDN). However, due to the computing model on GPU, the lookup latency is not so encouraging. In this paper, we shift the focus from GPU to Field-Programmable Gate Arrays (FPGA). We highlight three key challenges in(More)