Xian-Rong Guo

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The design of molecules with a specific structure and function is a long-term goal. The de novo design of proteins can not only shed light on the process of protein folding, but can also generate potentially functional proteins. [1] Much knowledge has been accumulated for secondary-structure design, [2] but the de novo design of stable tertiary structures(More)
Four new polycyclic antibiotics, citreamicin θ A (1), citreamicin θ B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus,(More)
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