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CXCL12/CXCR4 axis induced miR-125b promotes invasion and confers 5-fluorouracil resistance through enhancing autophagy in colorectal cancer
TLDR
In human CRC cells, it was found that the activation of CXCL12/CXCR4 axis promoted epithelial-mesenchymal transition (EMT) and concurrent upregulation of miR-125b and provided a potential therapeutic target in CRC.
Curcumin inhibits telomerase activity in human cancer cell lines.
TLDR
It is suggested that curcumin could suppress telomerase activity in the cancer cell lines and that the decrease of telomersase expression followed by induction of apoptosis might be involved in the anti-proliferating effect of curcuming.
MiR-214 increases the sensitivity of breast cancer cells to tamoxifen and fulvestrant through inhibition of autophagy
TLDR
MiR-214 increased the sensitivity of breast cancer cells to the 4-OHT/FUL-induced apoptosis through inhibition of autophagy by targeting UCP2, and shows potential as a novel therapeutic strategy for overcoming endocrine resistance in ER+ breast cancers.
Strategies to overcome or circumvent P-glycoprotein mediated multidrug resistance.
TLDR
This review will report on the recent advances in various strategies for overcoming or circumventing MDR mediated by P-glycoprotein.
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