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Anti-tumour immune activation by checkpoint inhibitors leads to durable responses in a variety of cancers, but combination approaches are required to extend this benefit beyond a subset of patients. In preclinical models tumour-derived VEGF limits immune cell activity while anti-VEGF augments intra-tumoral T-cell infiltration, potentially through vascular(More)
This paper introduces two kinds of handover algorithms that adjust the handover (HO) parameters of LTE (Long-Term Evolution) eNodeB (evolved NodeB) to improve the overall network performance and diminish negative effects. The focus is on the impact that two kinds of handover algorithms compare to A3 event based on the optimization of hysteresis and(More)
  • Christian von Hirschhausen, Claudio Marcantonini, Xian He, Jonas Egerer, Jean-Michel Glachant
  • 2012
Contents Acknowledgements i Executive Summary iii 1. Introduction 1 2. Trans-regional coordination and the potential role of the EU: The case of transmission infrastructures 4 2.1 Economic rationale for EU involvement and harmonization 4 2.1.1 Is any trans-national involvement justified on the grounds of subsidiarity? 4 2.1.2 Is there any economic rationale(More)
We present a performance analysis of a two-state heat engine model working with a single-mode radiation field in a cavity. The heat engine cycle consists of two adiabatic and two isoenergetic processes. Assuming the wall of the potential moves at a very slow speed, we determine the optimization region and the positive work condition of the heat engine(More)
He, Xian, "Uncertainty quantification and calibration of physical models" (2015). Open Access Dissertations. 469. To the best of my knowledge and as understood by the student in the Thesis/Dissertation Agreement, Publication Delay, and Certification/Disclaimer (Graduate School Form 32), this thesis/dissertation adheres to the provisions of Purdue(More)
MELANOMA BRIDGE 2015 KEYNOTE SPEAKER PRESENTATIONS Molecular and immuno-advances K1 Immunologic and metabolic consequences of PI3K/AKT/mTOR activation in melanoma Vashisht G. Y. Nanda, Weiyi Peng, Patrick Hwu, Michael A. Davies K2 Non-mutational adaptive changes in melanoma cells exposed to BRAF and MEK inhibitors help the establishment of drug resistance(More)
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