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Cordycepol C, a novel sesquiterpene isolated from the cultured mycelia of Cordyceps ophioglossoides, contains a hydroperoxy group and is cytotoxic to HepG2 cells. So far, no sesquiterpenes have been found in the genus Cordyceps and it would be interesting to investigate the antitumor efficacy as well as the mechanism of action of this unusual sesquiterpene.(More)
STUDY DESIGN A retrospective study of magnetic resonance imaging of the lower lumbar spine. OBJECTIVE To describe the characteristics of the concave angle of vertebral endplate (CAVE) and study the association between CAVE and lumbar intervertebral disc degeneration (IVDD). SUMMARY OF BACKGROUND DATA The vertebral endplate is responsible for(More)
BACKGROUND Because the prevalence of connective tissue disease (CTD)-associated interstitial lung disease (ILD; CTD-ILD) in China is unknown, we wanted to analyze the clinical characteristics of this disease in Chinese patients. METHODS The medical records of patients who received a diagnosis of ILD and treated in Shanghai Pulmonary Hospital from January(More)
We present a performance analysis of a two-state heat engine model working with a single-mode radiation field in a cavity. The heat engine cycle consists of two adiabatic and two isoenergetic processes. Assuming the wall of the potential moves at a very slow speed, we determine the optimization region and the positive work condition of the heat engine(More)
The immunomodulatory drug (IMiD) thalidomide and its structural analogs lenalidomide and pomalidomide are highly effective in treating clinical indications. Thalidomide binds to cereblon (CRBN), a substrate receptor of the cullin-4 really interesting new gene (RING) E3 ligase complex. Here, we examine the effect of thalidomide and its analogs on CRBN(More)
OBJECTIVE To investigate the molecular mechanism of adiponectin inhibiting activation of hepatic stellate cells in non-alcoholic fatty liver fibrosis. METHODS The rat models of non-alcoholic fatty liver fibrosis were successfully established by fat-rich diet administration. The expression of adiponectin mRNA and protein were respectively detected by(More)
Immunomodulatory drugs such as thalidomide, lenalidomide, and pomalidomide exhibit high responsive rates for newly identified or relapsed multiple myeloma patients. However, their mechanisms of action are not completely understood. One mechanism involves the ubiquitination and degradation of two transcription factors, IKZF1 and IKZF3. Whether there are(More)
This paper introduces two kinds of handover algorithms that adjust the handover (HO) parameters of LTE (Long-Term Evolution) eNodeB (evolved NodeB) to improve the overall network performance and diminish negative effects. The focus is on the impact that two kinds of handover algorithms compare to A3 event based on the optimization of hysteresis and(More)
Lung-targeting drugs are thought to be potential therapies of refractory lung diseases by maximizing local drug concentrations in the lung to avoid systemic circulation. However, a major limitation in developing lung-targeted drugs is the acquirement of lung-specific ligands. Pulmonary surfactant protein A (SPA) is predominantly synthesized by type II(More)
BACKGROUND In this study, we sought to identify differentially expressed proteins in the serum of patients with sarcoidosis or tuberculosis and to evaluate these proteins as markers for the differential diagnosis of sarcoidosis and sputum-negative tuberculosis. METHODS Using protein microarrays, we identified 3 proteins exhibiting differential expression(More)