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Biochemical and functional characterization of three activated macrophage populations
We generated three populations of macrophages (Mφ) in vitro and characterized each. Classically activated Mφ (Ca‐Mφ) were primed with IFN‐γ and stimulated with LPS. Type II‐activated Mφ (Mφ‐II) wereExpand
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Interleukin‐10: new perspectives on an old cytokine
Summary: Interleukin‐10 (IL‐10) has long been recognized to have potent and broad‐spectrum anti‐inflammatory activity, which has been unequivocally established in various models of infection,Expand
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Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects.
The hippocampal dentate gyrus in the adult mammalian brain contains neural stem/progenitor cells (NS/PCs) capable of generating new neurons, i.e., neurogenesis. Most drugs of abuse examined to dateExpand
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Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD
Impairment of working memory is one of the most important deleterious effects of marijuana intoxication in humans, but its underlying mechanisms are presently unknown. Here, we demonstrate that theExpand
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NF-κB1 (p50) Homodimers Differentially Regulate Pro- and Anti-inflammatory Cytokines in Macrophages*
NF-κB/Rel is a family of transcription factors whose activation has long been linked to the production of inflammatory cytokines. Here, we studied NF-κB signaling in the regulation of theExpand
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Tumor-Associated Microglia/Macrophages Enhance the Invasion of Glioma Stem-like Cells via TGF-β1 Signaling Pathway
The invasion of malignant glioma cells into the surrounding normal brain tissues is crucial for causing the poor outcome of this tumor type. Recent studies suggest that glioma stem-like cells (GSLCs)Expand
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TAC1, a major quantitative trait locus controlling tiller angle in rice.
A critical step during rice (Oryza sativa) cultivation is dense planting: a wider tiller angle will increase leaf shade and decrease photosynthesis efficiency, whereas a narrower tiller angle makesExpand
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Activation of Murine Macrophages
Our understanding of cell mediated immunity (CMI) has revealed the importance of activated macrophages as key immune effector cells. Over the past decade, we have come to realize that macrophagesExpand
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ERK Activation Following Macrophage FcγR Ligation Leads to Chromatin Modifications at the IL-10 Locus1
We have previously demonstrated that macrophages stimulated in the presence of immune complexes produce high levels of IL-10. We now examine the mechanism of IL-10 superinduction. We report that theExpand
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The role of NF-kappaB in the regulation of cell stress responses.
Nuclear factor-kappaB (NF-kappaB) is one of the key regulatory molecules in oxidative stress-induced cell activation. NF-kappaB is normally sequestered in the cytoplasm of nonstimulated cells andExpand
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