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To determine the site and mechanism of suppression by regulatory T (Treg) cells, we investigated their migration and function in an islet allograft model. Treg cells first migrated from blood to the inflamed allograft where they were essential for the suppression of alloimmunity. This process was dependent on the chemokine receptors CCR2, CCR4, and CCR5 and(More)
RATIONALE Vascular calcification is a hallmark of atherosclerosis, a major cause of morbidity and mortality in the United States. We have previously reported that the osteogenic transcription factor Runx2 is an essential and sufficient regulator of calcification of vascular smooth muscle cells (VSMC) in vitro. OBJECTIVE To determine the contribution of(More)
Glut-1 deficiency syndrome (Glut-1 DS, OMIM #606777) is characterized by infantile seizures, developmental delay, acquired microcephaly and hypoglycorrhachia. It is caused by haploinsufficiency of the blood-brain barrier hexose carrier. Heterozygous mutations or hemizygosity of the GLUT-1 gene cause Glut-1 DS. We generated a heterozygous haploinsufficient(More)
This paper proposes a new approach for emotion recognition based on a hybrid of hidden Markov models (HMMs) and artificial neural network (ANN), using both utterance and segment level information from speech. To combine the advantage on capability to dynamic time warping of HMMs and pattern recognition of ANN, the utterance is viewed as a series of voiced(More)
We propose an intelligent e-learning system featuring with affective agent tutor. The agent tutor "Alice" is not only fully aware of the affective state of the students through facial expression, speech and text, but also fully capable of adapting to these states wisely guided by a case-based method with facial expression generation and emotional speech(More)
OBJECTIVE Clinical and experimental studies demonstrate the important roles of vascular smooth muscle cells (VSMC) in the pathogenesis of atherosclerosis. We have previously determined that the osteogenic transcription factor Runx2 is essential for VSMC calcification. The present study characterized Runx2-regulated signals and their potential roles in(More)
FTY720 is a sphingosine-derived immunosuppressant. Phosphorylated FTY720 promotes T cell homing from spleen and peripheral blood to LNs by acting as an agonist for sphingosine-1-phosphate (S1P) receptors. Here we demonstrate that FTY720 enhances the activity of the sphingosine transporter Abcb1 (Mdr1) and the leukotriene C(4) transporter Abcc1 (Mrp1). Both(More)
Speech emotion recognition as a significant part has become a challenge to artificial emotion. It is particularly difficult to recognize emotion independent of the person concentrating on the speech channel. In the paper, an integrated system of hidden Markov model (HMM) and support vector machine (SVM), which combining advantages on capability to dynamic(More)