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Clinical, experimental, and genomic differences between intermediately pathogenic, highly pathogenic, and epidemic Streptococcus suis.
BACKGROUND Streptococcus suis emerged to cause an unusual outbreak of streptococcal toxic-shock-like syndrome (STSLS) in 2005. The mechanisms involved are unknown. METHODS Clinical, laboratory, andExpand
Isolation of an anti-tumor polysaccharide from Auricularia polytricha (jew’s ear) and its effects on macrophage activation
To investigate the active compound and its mechanism of the anti-tumor effects of Auricularia polytricha, the polysaccharides were isolated and its effects on macrophages were tested. ByExpand
Isolation and characterization of exopolysaccharide with immunomodulatory activity from fermentation broth of Morchella conica
Background and the purpose of this studyMushroom polysaccharides have traditionally been used for the prevention and treatment of a multitude of disorders like infectious illnesses, cancers andExpand
Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo
ABSTRACT Human Atg4 homologs are cysteine proteases, which play key roles in the macroautophagy/autophagy process by cleaving Atg8 homologs for conjugation to lipid membranes and for deconjugation ofExpand
Hypomethylation of LINE-1 elements in schizophrenia and bipolar disorder.
Schizophrenia (SCZ) and bipolar disorder (BPD) are severe mental illnesses with evidence of significant genetic and environmental etiological elements in their complex etiologies. 5'-MethylcytosineExpand
Clinical drug‐drug interaction assessment of ivacaftor as a potential inhibitor of cytochrome P450 and P‐glycoprotein
Ivacaftor is approved in the USA for the treatment of cystic fibrosis (CF) in patients with a G551D‐CFTR mutation or one of eight other CFTR mutations. A series of in vitro experiments conductedExpand
Immunosuppressive activity of pogostone on T cells: Blocking proliferation via S phase arrest.
Pogostone (PO) is one of the major chemical constituents of the essential oil of Pogostemon cablin (Blanco) Benth. In the present study, the effect of PO on T cell responsiveness was investigated toExpand
MicroRNA-381 protects myocardial cell function in children and mice with viral myocarditis via targeting cyclooxygenase-2 expression.
The present study aimed to determine the expression of cyclooxygenase (COX)-2 and microRNA (miRNA/miR)-381 in the blood of children with viral myocarditis (VM), and investigate the associationExpand
Rapid and Sensitive Detection of Shigella spp. and Salmonella spp. by Multiple Endonuclease Restriction Real-Time Loop-Mediated Isothermal Amplification Technique
Shigella and Salmonella are frequently isolated from various food samples and can cause human gastroenteritis. Here, a novel multiple endonuclease restriction real-time loop-mediated isothermalExpand
SNP Variation of RELN Gene and Schizophrenia in a Chinese Population: A Hospital-Based Case–Control Study
Aims: We aimed to explore whether RELN contributes to the vulnerability and severity of clinical symptoms of schizophrenia (SZ) in a Chinese population. Methods: The following were conducted in anExpand