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Link-layer fairness models that have been proposed for wireline and packet cellular networks cannot be generalized for shared channel wireless networks because of the unique characteristics of the wireless channel, such as location-dependent contention, inherent conflict between optimizing channel utilization and achieving fairness, and the absence of any(More)
Cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-binding cassette (ABC) transporter that functions as a chloride channel. Nucleotide-binding domain 1 (NBD1), one of two ABC domains in CFTR, also contains sites for the predominant CF-causing mutation and, potentially, for regulatory phosphorylation. We have determined crystal structures(More)
The epithelium lining the airways of the adult human lung is composed of ciliated and secretory cells together with undifferentiated basal cells (BCs). The composition and organization of this epithelium is severely disrupted in many respiratory diseases. However, little is known about the mechanisms controlling airway homeostasis and repair after(More)
CONTEXT Antibody-based induction therapy plus calcineurin inhibitors (CNIs) reduce acute rejection rates in kidney recipients; however, opportunistic infections and toxic CNI effects remain challenging. Reportedly, mesenchymal stem cells (MSCs) have successfully treated graft-vs-host disease. OBJECTIVE To assess autologous MSCs as replacement of antibody(More)
In mammals, one of the most pronounced consequences of viral infection is the induction of type I interferons, cytokines with potent antiviral activity. Schlafen (Slfn) genes are a subset of interferon-stimulated early response genes (ISGs) that are also induced directly by pathogens via the interferon regulatory factor 3 (IRF3) pathway. However, many ISGs(More)
Wnt signaling plays pivotal roles in the regulation of embryogenesis and cancer development. Xenopus Dapper (Dpr) was identified as an interacting protein for Dishevelled (Dvl), a Wnt signaling mediator, and modulates Wnt signaling. However, it is largely unclear how Dpr regulates Wnt signaling. Here, we present evidence that human Dpr1, the ortholog of(More)
Bioinformatics is an emerging and rapidly evolving discipline. The bioinformatics literature is growing exponentially. This paper aims to provide an integrated bibliometric study of the knowledge base of Chinese research community, based on the bibliometric information in the field of bioinformatics from SCI-Expanded database during the period of 2000–2005.(More)
Two extremely halophilic archaeal strains, designated TNN44(T) and TNN58(T), were isolated from Tainan marine solar saltern near Lianyungang city, Jiangsu province, China. Cells of the two strains were pleomorphic and Gram-stain-negative; colonies were red-pigmented. Strains TNN44(T) and TNN58(T) were able to grow at 20-50 °C (optimum 37 °C for both), in(More)