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The cortical surface correlates of clinical manifestations in the mid-stage sporadic Parkinson’s disease
The data suggested that the dysfunctions of these brain regions contributed by the cortical surface lesion were closely correlated with some clinical manifestations of mid-stage sPD.
The Possible Damaged Mechanism and the Preventive Effect of Monosialotetrahexosylganglioside in a Rat Model of Cerebral Ischemia-Reperfusion Injury.
- J. Zhang, Xin Fang, +6 authors Renshi Xu
- MedicineJournal of stroke and cerebrovascular diseases…
- 1 July 2015
The findings further support that the abnormal release and/or reuptake of excitatory amino acid neurotransmitters, the disordered calcium homeostasis and the excessive production and/ or reduced elimination of reactive oxygen species contribute to the pathogenesis of CIRI, and GM1 can partially prevent these pathogenesises to exert the protective effect on CIRi.
An Astrocyte Regenerative Response from Vimentin-Containing Cells in the Spinal Cord of Amyotrophic Lateral Sclerosis's Disease-Like Transgenic (G93A SOD1) Mice
The results suggested that there was a potential astrocyte regenerative response to motor neuron degeneration in motor neurons-degenerated regions in the adult spinal cord during the onset and progression stages of ALS-like disease.
The cortical thickness correlates of clinical manifestations in the mid-stage sporadic Parkinson’s disease
- Xia Deng, Chunyan Tang, +5 authors Ren-shi Xu
- Medicine, PsychologyNeuroscience Letters
- 28 October 2016
The data showed that the cortical thinning in the right frontal Orb, rectus and cingulum were the pathological base of some clinical manifestations including the cognitive impairment, hallucinations, psychosis, the depressed mood, the anxious mood, apathy, the sleep problems, the nighttime or/and daytime sleepiness, the short term memory stores and the central execution in the mid-stage sPD patients.
The possible mechanism of Parkinson’s disease progressive damage and the preventive effect of GM1 in the rat model induced by 6-hydroxydopamine
Data suggested that dysfunction of excitatory amino acids neurotransmitter, calcium homeostasis disorder, abnormal metabolism of oxygen free radicals, abnormal trace elements distribution and/or deposition and excessive apoptosis participated in the progressive process of PD, and that GM1 could partially prevent the progressive damage.
The Potential Mutation of GAK Gene in the Typical Sporadic Parkinson’s Disease from the Han Population of Chinese Mainland
The data suggest that the multiple SNPs of GAK synergistically participate in the pathogenesis of sPD through multiple pathways.
The Alterations of Cortical Volume, Thickness, Surface, and Density in the Intermediate Sporadic Parkinson's Disease from the Han Population of Mainland China
The data indicated that the deficits of extensive brain regions involved in the development of sPD, resulted in a series of correspondent complex clinical manifestations in the disease.
Five-Minute Cognitive Test as A New Quick Screening of Cognitive Impairment in The Elderly
The FCT is a novel, reliable, and valid cognitive screening test for the detection of dementia at early stages and its diagnostic performance was superior to that of MMSE in the same cohort.
Cortical Structural Connectivity Alterations and Potential Pathogenesis in Mid-Stage Sporadic Parkinson’s Disease
- Xia Deng, Zheng Liu, Qin Kang, Lin Lu, Yu Zhu, Renshi Xu
- MedicineFrontiers in Aging Neuroscience
- 31 May 2021
It is suggested that the extensive alteration of cortical structural connectivity is one of possible pathogenesis resulting in the multiple and complex clinical symptoms in sPD.