Xi-qian Xing

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Statins are the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors that function as potent inhibitors of cholesterol biosynthesis and have been used for many years for the treatment of hypercholesterolemia. However, accumulating experimental and clinical studies have revealed that the health benefits associated with statins treatment, particularly(More)
Accumulating evidence suggests that statins possess anti-inflammatory properties and may decrease C-reactive protein (CRP) levels in plasma. However, no studies have as yet addressed whether or not statins regulate the expression of CRP in human lung epithelial cells (A549). In this study, we determined whether atorvastatin modulates the lipopolysaccharide(More)
Pulmonary hypertension (PH) is a cardiovascular disorder characterized by vasoconstriction and vascular remodeling. Recently, rapidly increasing evidence from various rat models of PH and patients with PH suggest that small GTPase Rho and its downstream effector, Rho-kinase, play a key role in the pathogenesis of PH. Activation of the Rho/Rho-kinase pathway(More)
e admitted a 59-year-old man with a 1-year history Fig 3. Wof chest pain to our hospital for further evaluation and management. Results from myocardial enzyme analysis and electrocardiography were normal. The crosssection of chest computed tomography revealed multiple calcified nodules from the anterolateral into the airway lumen, the volume rendering(More)
Pulmonary hypertension is characterized by extensive vascular remodelling, leading to increased pulmonary vascular resistance and eventual death due to right heart failure. The pathogenesis of pulmonary hypertension involves vascular endothelial dysfunction and disordered vascular smooth muscle cell (VSMC) proliferation and migration, but the exact(More)
To cite: Xing X-Q, Xiao Y, Liu Y-H, et al. Thorax Published Online First: [please include Day Month Year] doi:10.1136/thoraxjnl2015-207935 IMAGING AND BRONCHOSCOPIC FINDINGS A 43-year-old woman presented with cough and gradually aggravating exertional dyspnoea of 5 months’ duration. She had undergone a hysteromyomectomy for myoma uteri 3 years previously.(More)
To the Editor: A 49‐year‐old man presented with a cough and short of breathing for 3 months’ duration. He went to different hospitals and received treatment of antibiotics for pneumonia in the left low lobe. On physical examination, cyanosis of lips and auscultation of the chest showed the left‐side breath sounds decreased. Computed tomographic (CT) scan,(More)