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Expression of focal adhesion kinase and alpha5 and beta1 integrins in carcinomas and its clinical significance.
AIM To detect the expression pattern of FAK (focal adhesion kinase) and integrin alpha5 and beta1 subunits in different kinds of cancerous tissues and to study their correlation withExpand
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Localization of &agr;-synuclein to mitochondria within midbrain of mice
The interrelationship between &agr;-synuclein (&agr;-syn) and mitochondria is not clearly understood. Owing to the lack of the signal peptide and its predominant localization in the cytosol,Expand
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PPARγ activator rosiglitazone inhibits cell migration via upregulation of PTEN in human hepatocarcinoma cell line BEL-7404
PPARγ agonists were reported to be implicated in many biological functions in certain kinds of cells, however, little is known about the effects of PPARγ on hepatocarcinoma cell. We explored theExpand
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Expression of focal adhesion kinase and α5 and β1 integrins in carcinomas and its clinical significance
AIM: To detect the expression pattern of FAK (focal adhesion kinase) and integrin α5 and β1 subunits in different kinds of cancerous tissues and to study their correlation with clinicopathologicalExpand
  • 48
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Protein phosphatase activity of PTEN inhibited the invasion of glioma cells with epidermal growth factor receptor mutation type III expression
  • X. Cai, B. Tao, +5 authors X. Zha
  • Biology, Medicine
  • International journal of cancer
  • 20 December 2005
PTEN is a major tumor suppressor gene that has been shown to inhibit cell invasion. Its mutation has been found in 20–40% of malignant gliomas. Meanwhile, the type III EGFR mutation (EGFRvIII), whichExpand
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Profilin 1 obtained by proteomic analysis in all-trans retinoic acid-treated hepatocarcinoma cell lines is involved in inhibition of cell proliferation and migration.
Previous studies have shown that all-trans retinoic acid (ATRA) suppresses growth of hepatocarcinoma cell in vitro. To understand the underlying mechanisms, we investigated the protein expressionExpand
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TGF-β1 Modulated the Expression of α5β1 Integrin and Integrin-Mediated Signaling in Human Hepatocarcinoma Cells
Abstract Integrins are a family of cell surface adhesion molecules which mediate cell adhesion and initiate signaling pathways that regulate cell spreading, migration, differentiation, andExpand
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The membrane-cytoskeleton organizer ezrin is necessary for hepatocellular carcinoma cell growth and invasiveness
  • Y. Zhang, Mei-yu Hu, +4 authors K. Liu
  • Medicine, Biology
  • Journal of Cancer Research and Clinical Oncology
  • 20 June 2006
PurposeThe change of cell mobility is one of the preconditions of tumor metastasis. Cell skeleton alteration and rearrangement of F-actin was closely related to cell mobility. Ezrin is aExpand
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Expression of the integrinα5 subunit and its mediated cell adhesion in hepatocellular carcinoma
Tumor invasion and metastasis are complex processes, requiring the ability of tumor cells to interact with proteins of the extracellular matrix through cell-adhesion molecules on the cell surface.Expand
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The relationship between PTEN expression and anoikis in human lung carcinoma cell lines.
The relationship between PTEN expression and anoikis in 8 different human lung carcinoma cell (HLCC) lines, and PKB and FAK effects in the process were studied. Northern blots and Western blots wereExpand
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