Xi Juan Zhao

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p53 is a frequent target for mutation in human tumors, and mutant p53 proteins can actively contribute to tumorigenesis. We employed a three-dimensional culture model in which nonmalignant breast epithelial cells form spheroids reminiscent of acinar structures found in vivo, whereas breast cancer cells display highly disorganized morphology. We found that(More)
In this paper, we focus on discrete expression classification using dynamic 3D sequences (4D data) recording the facial movements. A robust approach for registering 4D data is proposed and a variant of local binary patterns on three orthogonal planes is used for feature extraction. We present a fully automatic facial expression recognition pipeline. The(More)
The spatial relationship between different objects plays an important role in defining the context of scenes. Most previous 3D classification and retrieval methods take into account either the individual geometry of the objects or simple relationships between them such as the contacts or adjacencies. In this article we propose a new method for the(More)
a r t i c l e i n f o Facial expression analysis has interested many researchers in the past decade due to its potential applications in various fields such as human–computer interaction, psychological studies, and facial animation. Three-dimensional facial data has been proven to be insensitive to illumination condition and head pose, and has hence(More)
This study uses National Violence against Women Survey data to investigate the differential impact of concomitant forms of violence (sexual abuse, stalking, and psychological abuse) and ethnicity on help-seeking behaviors of women physically abused by an intimate partner (n = 1,756). Controlling for severity of the physical abuse, women who experienced(More)
Expression profiles of primary breast tumors were investigated in relation to disseminated tumor cells (DTCs) in bone marrow (BM) in order to increase our understanding of the dissemination process. Tumors were classified into five pre-defined molecular subtypes, and presence of DTC identified (at median 85 months follow-up) a subgroup of luminal A patients(More)
The retromer is a protein complex that mediates retrograde transport of transmembrane cargoes from endosomes to the trans-Golgi network (TGN). It is comprised of a cargo-selection subcomplex of Vps26, Vps29 and Vps35 and a membrane-binding coat subcomplex of sorting nexins (SNXs). Previous studies identified SNX1/2 as one of the components of the SNX(More)
Due to the increasing popularity of mobile technologies, sensitive user information is often stored on mobile devices. However, the essential task of mobile user authentication is rendered more challenging by the conflicting requirements of security and usability: usable solutions are often insecure, while secure solutions hinder device accessibility. In(More)
Many transfection techniques can deliver biomolecules into cells, but the dose cannot be controlled precisely. Delivering well-defined amounts of materials into cells is important for various biological studies and therapeutic applications. Here, we show that nanochannel electroporation can deliver precise amounts of a variety of transfection agents into(More)
Recurrent mutations in histone-modifying enzymes imply key roles in tumorigenesis, yet their functional relevance is largely unknown. Here, we show that JARID1B, encoding a histone H3 lysine 4 (H3K4) demethylase, is frequently amplified and overexpressed in luminal breast tumors and a somatic mutation in a basal-like breast cancer results in the gain of(More)