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Molecular signatures of G-protein-coupled receptors.

• A J Venkatakrishnan, Xavier Deupí, Guillaume Lebon, Christopher G. Tate, Gebhard F. X. Schertler, M. Madan Babu
• Nature
• 2013

G-protein-coupled receptors (GPCRs) are physiologically important membrane proteins that sense signalling molecules such as hormones and neurotransmitters, and are the targets of several prescribed… (More)

Conformational complexity of G-protein-coupled receptors.

• Brian K. Kobilka, Xavier Deupí
• Trends in pharmacological sciences
• 2007

G-protein-coupled receptors (GPCRs) are remarkably versatile signaling molecules. Members of this large family of membrane proteins respond to structurally diverse ligands and mediate most… (More)

Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists.

• Gayathri Swaminath, Xavier Deupí, +4 authors Brian K. Kobilka
• The Journal of biological chemistry
• 2005

The beta(2) adrenergic receptor (beta(2)AR) is a prototypical family A G protein-coupled receptor (GPCR) and an excellent model system for studying the mechanism of GPCR activation. The beta(2)AR… (More)

The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation.

• Cédric Govaerts, Cyrille Blanpain, +6 authors Maryline Parmentier
• The Journal of biological chemistry
• 2001

CCR5 is a G-protein-coupled receptor activated by the chemokines RANTES (regulated on activation normal T cell expressed and secreted), macrophage inflammatory protein 1alpha and 1beta, and monocyte… (More)

Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II.

• Xavier Deupí, Patricia Edwards, +4 authors Joerg Standfuss
• Proceedings of the National Academy of Sciences…
• 2012

G protein-coupled receptors (GPCR) are seven transmembrane helix proteins that couple binding of extracellular ligands to conformational changes and activation of intracellular G proteins, GPCR… (More)

Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor.

• Xiaojie Yao, Charles Parnot, +4 authors Brian K. Kobilka
• Nature chemical biology
• 2006

G protein-coupled receptors (GPCRs) regulate a wide variety of physiological functions in response to structurally diverse ligands ranging from cations and small organic molecules to peptides and… (More)

Activation of G protein-coupled receptors.

• Xavier Deupí, Brian K. Kobilka
• Advances in protein chemistry
• 2007

G protein-coupled receptors (GPCRs) mediate responses to hormones and neurotransmitters, as well as the senses of sight, smell, and taste. These remarkably versatile signaling molecules respond to… (More)

Structural insights into agonist-induced activation of G-protein-coupled receptors.

• Xavier Deupí, Joerg Standfuss
• Current opinion in structural biology
• 2011

Recent years have seen tremendous breakthroughs in structure determination of G-protein-coupled receptors (GPCRs). In 2011, two agonist-bound active-state structures of rhodopsin have been published.… (More)

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region

• A. J. Venkatakrishnan, Xavier Deupí, +9 authors M. Madan Babu
• Nature
• 2016

Class A G-protein-coupled receptors (GPCRs) are a large family of membrane proteins that mediate a wide variety of physiological functions, including vision, neurotransmission and immune responses.… (More)

Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3.

• Cédric Govaerts, Antoine Bondue, +7 authors Cédric Blanpain
• The Journal of biological chemistry
• 2003

CCR5 is a G protein-coupled receptor responding to four natural agonists, the chemokines RANTES (regulated on activation normal T cell expressed and secreted), macrophage inflammatory protein (MIP)-1… (More)

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