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G-protein-coupled receptors (GPCRs) are physiologically important membrane proteins that sense signalling molecules such as hormones and neurotransmitters, and are the targets of several prescribed… (More)
- Xavier Deupí, Patricia Edwards, +4 authors Joerg Standfuss
- Proceedings of the National Academy of Sciences…
- 2012
G protein-coupled receptors (GPCR) are seven transmembrane helix proteins that couple binding of extracellular ligands to conformational changes and activation of intracellular G proteins, GPCR… (More)
- Xiaojie Yao, Charles Parnot, +4 authors Brian K. Kobilka
- Nature chemical biology
- 2006
G protein-coupled receptors (GPCRs) regulate a wide variety of physiological functions in response to structurally diverse ligands ranging from cations and small organic molecules to peptides and… (More)
- Eneko Urizar, Sylvie Claeysen, +4 authors Leonardo Pardo
- The Journal of biological chemistry
- 2005
We aimed at understanding molecular events involved in the activation of a member of the G protein-coupled receptor family, the thyrotropin receptor. We have focused on the transmembrane region and… (More)
- Cédric Govaerts, Cédric Blanpain, +6 authors Marc Parmentier
- The Journal of biological chemistry
- 2001
CCR5 is a G-protein-coupled receptor activated by the chemokines RANTES (regulated on activation normal T cell expressed and secreted), macrophage inflammatory protein 1alpha and 1beta, and monocyte… (More)
- Xavier Deupí, Joerg Standfuss
- Current opinion in structural biology
- 2011
Recent years have seen tremendous breakthroughs in structure determination of G-protein-coupled receptors (GPCRs). In 2011, two agonist-bound active-state structures of rhodopsin have been published.… (More)
- Gayathri Swaminath, Xavier Deupí, +4 authors Brian K. Kobilka
- The Journal of biological chemistry
- 2005
The beta(2) adrenergic receptor (beta(2)AR) is a prototypical family A G protein-coupled receptor (GPCR) and an excellent model system for studying the mechanism of GPCR activation. The beta(2)AR… (More)
- Juan Antonio Ballesteros, Xavier Deupí, Mireia Olivella, Eric E. J. Haaksma, Leonardo Pardo
- Biophysical journal
- 2000
The relationship between the Ser, Thr, and Cys side-chain conformation (chi(1) = g(-), t, g(+)) and the main-chain conformation (phi and psi angles) has been studied in a selection of protein… (More)
- Mireia Olivella, Xavier Deupí, Cédric Govaerts, Leonardo Pardo
- Biophysical journal
- 2002
The influence of the solvent on the main-chain conformation (phi and Psi dihedral angles) of alpha-helices has been studied by complementary approaches. A first approach consisted in surveying… (More)
- A. J. Venkatakrishnan, Xavier Deupí, +9 authors M. Madan Babu
- Nature
- 2016
Class A G-protein-coupled receptors (GPCRs) are a large family of membrane proteins that mediate a wide variety of physiological functions, including vision, neurotransmission and immune responses.… (More)