Xabier Elcoroaristizabal Martín

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Manuel Fernández-Martínez, Xabier Elcoroaristizabal Martín, Elisa Blanco Martín, Luis Galdos Alcelay, Iratxe Ugarriza Serrano, Fernando Gómez Busto, Maite Álvarez-Álvarez, Ana Molano Salazar, Rocio Bereincua Gandarias, Sandra Inglés Borda, Juan María Uterga Valiente, Begoña Indakoetxea Juanbeltz, María Ángeles Gómez Beldarraín, Josefa Moraza López, Myriam(More)
BACKGROUND Many genes have been studied to determine how they might be involved in Alzheimer's disease (AD). Estrogens have a protective effect in the central nervous system. The mechanisms of action of estrogens are mediated by two estrogen receptors (ERs), ERα and ERβ. Thus, these genes could also play a role in the progression of amnesic mild cognitive(More)
OBJECTIVES Examine the role of single nucleotide polymorphisms (SNPs) in the oestrogen receptor (ER) genes: rs9340799, rs2234693, rs2228480 (in the ESR1 gene) and rs4986938 (in the ESR2 gene) as a risk factor for amnesic mild cognitive impairment (MCIa) and Alzheimer's disease (AD) and its possible association with the apolipoprotein E (APOE) gene. DESIGN(More)
INTRODUCTION Currently there are notable differences in the aging of individuals in modern populations. While some of them enjoy a long healthy aging, others develop neurodegenerative diseases, such as Alzheimer's disease (AD). Environmental factors are critical, but genetics could explain the differences observed. It has recently been postulated that(More)
The protein family known as synucleins is composed of α-, β- and γ-synuclein. The most widely studied is the α-synuclein protein due to its participation in essential processes of the central nervous system. Neurotoxicity of this protein is related to the presence of multiplications (duplications and triplications) and point mutations in the gene sequence(More)
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