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To investigate the effect of magnesium on nitric oxide synthase (NOS) of neurons in cortex during early cerebral ischemic period, a rat model of middle cerebral artery occlusion (MCAO) was established. The results showed that the NOS activity of neurons in cortex was increased significantly at 15 min after MCAO, reached its peak at 30 min after MCAO and(More)
5-Fluorouracil (5-Fu) is one of the most commonly used drugs to treat gastric cancer; however, drug-resistance in cancer cells reduces the efficacy of 5‑Fu. Celecoxib may be able to reduce resistance to 5‑Fu chemotherapy. The aim of the present study was to investigate the inhibitory effects of a combination of 5‑Fu and celecoxib on implanted gastric cancer(More)
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