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Combination Therapy Targeting Akt and Mammalian Target of Rapamycin Improves Functional Outcome after Controlled Cortical Impact in Mice
Akt and mammalian target of rapamycin (mTOR) are both activated after traumatic brain injury (TBI), however complex interplay between the two hampers deciphering their functional implications inExpand
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High-Mobility Group Box 1 Promotes Metalloproteinase-9 Upregulation Through Toll-Like Receptor 4 After Cerebral Ischemia
Background and Purpose— HMGB1 is a nuclear protein and an alarmin that signals cell damage in response to injury. It is believed that after release from injured cells, HMGB1 binds to its receptors toExpand
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Maternal exposure to fine particulate matter (PM2.5) and pregnancy outcomes: a meta-analysis
A growing body of evidence has investigated the association between maternal exposure to PM2.5 (particulate matter with aerodynamic diameter 2.5 μm) during pregnancy and adverse pregnancy outcomes.Expand
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Activation of Sirt1 by Resveratrol Inhibits TNF-α Induced Inflammation in Fibroblasts
Inflammation is one of main mechanisms of autoimmune disorders and a common feature of most diseases. Appropriate suppression of inflammation is a key resolution to treat the diseases. Sirtuin1Expand
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Tumor Necrosis Factor Alpha and Fas Receptor Contribute to Cognitive Deficits Independent of Cell Death after Concussive Traumatic Brain Injury in Mice
Tumor necrosis factor alpha (TNFα) and Fas receptor contribute to cell death and cognitive dysfunction after focal traumatic brain injury (TBI). We examined the role of TNFα/Fas in postinjuryExpand
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Auditory efferent feedback system deficits precede age‐related hearing loss: Contralateral suppression of otoacoustic emissions in mice
The C57BL/6J mouse has been a useful model of presbycusis, as it displays an accelerated age‐related peripheral hearing loss. The medial olivocochlear efferent feedback (MOC) system plays a role inExpand
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Adipokines in Psoriatic Arthritis Patients: The Correlations with Osteoclast Precursors and Bone Erosions
Significant bone remodeling with disordered osteoclastogenesis has been implicated in the pathogenesis of psoriatic arthritis (PsA). And there is a high prevalence of the metabolic syndrome (MS) inExpand
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ROS‐AKT‐mTOR axis mediates autophagy of human umbilical vein endothelial cells induced by cooking oil fumes‐derived fine particulate matters in vitro
Abstract Cooking oil fumes‐derived PM2.5 (COFs‐derived PM2.5) exposure can induce oxidative stress and cytotoxic effects. Here we investigated the role of ROS‐AKT‐mTOR axis in COFs‐derivedExpand
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Hormone replacement therapy diminishes hearing in peri-menopausal mice
We recently discovered that progestin in hormone replacement therapy (HRT) for post-menopausal women has detrimental effects on the ear and central auditory system [Guimaraes, P., Frisina, S.T.,Expand
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Sensorimotor control of vocal pitch production in Parkinson's disease
The present study was designed to investigate the sensorimotor control of voice fundamental frequency (F0) in individuals with Parkinson's diseases (PD). Fifteen Cantonese individuals with PD, andExpand
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