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Probucol promotes high glucose-induced proliferation and inhibits apoptosis by reducing reactive oxygen species generation in Müller cells
Probucol could inhibit intracellular ROS generation, promote proliferation, and decrease apoptosis of human retinal Müller cells cultured in high glucose and might also be associated with Keap1/Nrf2/ARE oxidative stress signaling pathway activation. Expand
Epigenetics in the diabetic retinopathy
Epigenetics palys a important role in many dieases, including diabetic retinopathy, and elucidateing the epigenetic mechanism of DR may provide a new direction for treating diabetes. Expand
Effects of probucol on high glucose-induced specificity protein 1/Keap1/Nrf2/glutamate-cysteine ligase catalytic in the cultured human müller cells
Objective To observe the expression of probucol on high glucose-induced specificity protein 1(SP1), kelchlike ECH associated protein1 (Keap1), NF-E2-related factor 2 (Nrf2) and glutamate-cysteineExpand