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Linkage analysis and association analysis in the presence of linkage using age at onset of COGA alcoholism data
Complex disease mapping usually involves a combination of linkage and association techniques. Linkage analysis can scan the entire genome in a few hundred tests. Association tests may involve an evenExpand
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A genome-wide tree- and forest-based association analysis of comorbidity of alcoholism and smoking
Genetic mechanisms underlying alcoholism are complex. Understanding the etiology of alcohol dependence and its comorbid conditions such as smoking is important because of the significant healthExpand
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Linkage analysis of longitudinal data and design consideration
BackgroundStatistical methods have been proposed recently to analyze longitudinal data in genetic studies. So far, little attention has been paid to examine the relationship among key factors inExpand
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Comparison of single‐nucleotide polymorphisms and microsatellite markers for linkage analysis in the COGA and simulated data sets for Genetic Analysis Workshop 14: Presentation Groups 1, 2, and 3
The papers in presentation groups 1–3 of Genetic Analysis Workshop 14 (GAW14) compared microsatellite (MS) markers and single‐nucleotide polymorphism (SNP) markers for a variety of factors, usingExpand
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Multivariate linkage analysis using the electrophysiological phenotypes in the COGA alcoholism data
Multivariate linkage analysis using several correlated traits may provide greater statistical power to detect susceptibility genes in loci whose effects are too small to be detected in univariateExpand
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Adaptation in aphasia: revisiting language evidence
ABSTRACT Background: Humans adapt to constantly changing internal and external conditions to meet survival needs. Persons with aphasia (PWA) are faced with changes in their physiological, cognitive,Expand
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Functional category production and degrees of severity: findings from Chinese agrammatism
ABSTRACT Background: People with agrammatism have profound deficits in producing functional categories. The Tree Pruning Hypothesis proposes that these deficits are attributed to the reduced abilityExpand